Molecular structure of Indomethacin Acyl-β-D-glucuronide, CAS Number: 75523-11-4
Indomethacin Acyl-β-D-glucuronide (CAS 75523-11-4)
Alternate Names:
Indomethacin Acyl-β-D-glucuronide is known as a Glucuronide metabolite of Indomethacin.
Application:
Indomethacin Acyl-β-D-glucuronide is a Glucuronide metabolite of Indomethacin, potentially implicated in the toxicity of many xenobiotics.
CAS Number:
75523-11-4
Molecular Weight:
533.91
Molecular Formula:
C25H24ClNO10
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Indomethacin Acyl-β-D-glucuronide is used in research as a tool for understanding chemical metabolism, particularly how compounds are processed through conjugation with glucuronic acid. It serves as a metabolite reference standard for the identification and quantification of chemical conjugates in biological samples using chromatographic analysis. Researchers utilize this compound to study the glucuronidation process, which is an important pathway for the biotransformation of many substances. The compound is also employed in enzyme assays to investigate the activity and specificity of glucuronosyltransferases, the enzymes responsible for the glucuronidation reaction.
Indomethacin Acyl-β-D-glucuronide (CAS 75523-11-4) References
- Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. | Kalgutkar, AS., et al. 2000. J Med Chem. 43: 2860-70. PMID: 10956194
- Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2. | Hata, AN., et al. 2005. Mol Pharmacol. 67: 640-7. PMID: 15563582
- Topography of prostaglandin H synthase. Antiinflammatory agents and the protease-sensitive arginine 253 region. | Kulmacz, RJ. 1989. J Biol Chem. 264: 14136-44. PMID: 2503512
- Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation. | Manevski, N., et al. 2015. Drug Metab Dispos. 43: 126-39. PMID: 25339109
- Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae. | Little, MS., et al. 2018. Proc Natl Acad Sci U S A. 115: E152-E161. PMID: 29269393
- The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel. | De Logu, F., et al. 2019. Pharmacol Res. 142: 127-139. PMID: 30794923
- Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats. | Zhang, X., et al. 2021. J Pharm Anal. 11: 200-209. PMID: 34012696
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indomethacin Acyl-β-D-glucuronide, 1 mg | sc-221756 | 1 mg | $416.00 | |||
Indomethacin Acyl-β-D-glucuronide, 2.5 mg | sc-221756A | 2.5 mg | $823.00 | |||
Indomethacin Acyl-β-D-glucuronide, 5 mg | sc-221756B | 5 mg | $1574.00 | |||
Indomethacin Acyl-β-D-glucuronide, 10 mg | sc-221756C | 10 mg | $2923.00 |