Molecular structure of Indomethacin, CAS Number: 53-86-1
Indomethacin (CAS 53-86-1)
See product citations (18)
Alternate Names:
1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid; Indocin
Application:
Indomethacin is an inhibitor of Cox-1 and activator of PPARγ
CAS Number:
53-86-1
Purity:
≥99%
Molecular Weight:
357.8
Molecular Formula:
C19H16ClNO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Indomethacin is a nonsteroidal compound extensively employed in research due to its strong inhibitory effects on cyclooxygenase (COX), an enzyme critical for the production of prostaglandins. In laboratory applications, it is utilized to probe the role of prostaglandins in inflammation and to understand their contribution to pain and fever mechanisms. Moreover, indomethacin serves as a model compound to study COX enzyme kinetics and the regulation of inflammatory pathways. It has been instrumental in elucidating the biochemistry of inflammation and the complex interplay of signaling molecules in various cell types. In addition to its utility in inflammation research, it is also used in experimental models to investigate the closure of patent ductus arteriosus, a condition typically occurring after birth.
Indomethacin (CAS 53-86-1) References
- Effect of cigarette smoke on pharmacokinetics of oral, intrarectal, or intravenous indomethacin in rats. | Yoshida, T., et al. 1991. Naunyn Schmiedebergs Arch Pharmacol. 344: 500-4. PMID: 1766476
- The anti-inflammatory drug indomethacin alters nanoclustering in synthetic and cell plasma membranes. | Zhou, Y., et al. 2010. J Biol Chem. 285: 35188-95. PMID: 20826816
- Metabolic fate of indometacin farnesil, a prodrug of indomethacin: characteristic biotransformation of indometacin farnesil in rats. | Mishima, M., et al. 1990. Xenobiotica. 20: 135-46. PMID: 2333710
- Indomethacin-induced de novo headache in hemicrania continua--fighting fire with fire? | Jürgens, TP., et al. 2013. Cephalalgia. 33: 1203-5. PMID: 23709499
- Evidence against the participation of a pharmacokinetic interaction in the protective effect of single-dose curcumin against gastrointestinal damage induced by indomethacin in rats. | Zazueta-Beltrán, L., et al. 2017. J Integr Med. 15: 151-157. PMID: 28285620
- Chronopharmacokinetics of indomethacin in rats. | Guissou, P., et al. 1987. Arzneimittelforschung. 37: 1034-7. PMID: 3435597
- Pentapeptide modified ethosomes for enhanced skin retention and topical efficacy activity of indomethacin. | Niu, J., et al. 2022. Drug Deliv. 29: 1800-1810. PMID: 35656937
- Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets. | Salari, H., et al. 1984. Prostaglandins Leukot Med. 13: 53-60. PMID: 6424136
- Bioavailability of indomethacin from two multiple-units controlled-release formulations. | Bechgaard, H., et al. 1982. Eur J Clin Pharmacol. 21: 511-5. PMID: 7075656
- Excretion of indomethacin into saliva following intravenous administration to dogs. | Watanabe, J., et al. 1981. J Pharmacobiodyn. 4: 336-44. PMID: 7288551
- Absorption of indomethacin from nasal cavity in rats. | Huang, ZL., et al. 1995. Zhongguo Yao Li Xue Bao. 16: 117-20. PMID: 7597909
- Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. | Meade, EA., et al. 1993. J Biol Chem. 268: 6610-4. PMID: 8454631
- Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. | Lehmann, JM., et al. 1997. J Biol Chem. 272: 3406-10. PMID: 9013583
Inhibitor of:
α-defensin 2, β-defensin 2, β-defensin 5, 4921521F21Rik, 9530003J23Rik, AADAC, AADACL1, AAT-1, ABC-1, ABCB6, ABCC12, ADH4, AKR1C12, AKR1C13, AKR1C18, AKR1C19, AKR1C20, AKR1C6, AKR1CL1, AKR1CL2, AKR7A5, ANXA8L2, AOX1, AOX3, AOX4, AQP1, AQP2, AQP5, AROS-29, BBS12, BC048943, BNIP-2, BTR1, C1s, C6, Calgranulin A, Carbonyl reductase 1, CatSperβ, CES7, CHAD, Chr-A, CLCA5_Clac5, Clca6, Collagen Type II, Cox, Cox-2, CPVL, CRP3, CTL2, CTL3, CTRB2, Cyp2c54, CysLT1 Receptor, cytohesin-4, Cytokeratin 14, D11Wsu47e, DBX1, Dkk-1, Ebola virus VP40, EG238829, EG436008, eosinophil peroxidase, EPX, ESAM, Fibrocystin, GFAP, GlcAT-S, Gm11062, GPD2, GRO, group II sPLA2, group IIE sPLA2, group IIF sPLA2, group III sPLA2, group IVC sPLA2, group IVF sPLA2, group XIIB sPLA2, HRASLS2, HRSP12, IFRG15, Igkv3-4, IL-1ε F6, IL-12, IL-16, IL-17B, ITF, L-FABP, LCE2D, Lipocalin-15, Lipocalin-6, Lipocalin-8, Lipocalin-9, LOC402377, LOC645485, LPLUNC3, LPO, LTB4DH, LZIP, MAB-5, Macrophagee Marker, MB67_CAR1/2, MFSD6L, MPST, MRGE, MRP1, NALP11, NAT-16, NGAL, NPT1, OAT1, OAT2, OAT3, OAT6, OATP-D, OATP-E, Olfr374, Olfr786, Olfr870, Olr245, Olr395, OPN1MW, OSCAR, P504S, PDP2, PGAM2, PGD synthase, PGE Synthase, PGE synthase 2, PGI2 synthase, PGRP-Iα, PGS1, PGT, PIPES, PLA2G4B, plasminogen, PLZF, Ptx3, PXDN, RDS, REG3α, retbindin, RFC-1, RUNX3, SAA3, SAA4, SDR39U1, Selenoprotein T, SerpinA3k, SerpinB9e, SLC17A (solute carrier family 17), SLC17A2, SLC17A4, SLC22A11, SLC22A14, Slc22a27, SLC22A29, SLC22A9, SLC26A6, SLC5 (solute carrier family 5; SLC5A), Slco6c1, Slco6d1, SMPDL3A, SPACA7, SPRR4, SULT1A4, SULT1B1, SULT1C2, SULT2B1, SVCT1, TEX13B, TMEM16A, TMPRSS11C, TREML2, TSARG4, UGRP2, UGT1A8, UGT2B, UGT2B1, UGT2B15, UGT2B17, UGT3A2, UGT8, UST1R, V-ATPase C2, Vacuolar ATPase (V-ATPase; ATP6), VPS51, Wnt-4, Ym1, ZBTB (Zinc finger BTB domain containing), and ZDHHC24.Activator of:
ABCA14, ABCA15, ABCC11, ABCD4, ABO Blood Group Antigens, Adipogenin, AF9, AKR1C14, AKR1C19, ALB, APC, Bob 1, bradykinin B1 R, BTN1A1, C4 A, CA XIV, carbonyl reductase 2, CD200R2, CES3, CPV CrmA, Cyp2c38, Cyp2c40, Cyp2c66, CYP2J8, Cyp4f13, Cyp4f17, Cyp4f39, Cyp4f40, CysLT1, DD1, DD2, DP2_CRTH2, Dpl, EBV viral capsid antigen, EG625716, Fc γ RIIb, FMO2, Gle1, GLIPR1, GLIS1, group XIIA sPLA2, HoxA2, HSV-2 gD, IFI-202, IKK-i, IL-1F5, IL-8RA, KCNMB2, Lce3f, Lewis Blood Group Antigen, LGR5, Lipocalin-6, MASGP-BP, MCP-3, MKP-1, MNS Blood Group Antigens, MRP3, MRP4, MRP6, Mucin 20, NLRC5, Nlrp12, OATP-H, Oatp-Y, pancpin, PPAR alpha, PPAR gamma, PPOX, PrP, Psg18, PTN, RT1-B, SBDS, sentan, SerpinB1, SerpinB1a, SIGIRR, SLC22A29, SLC35D3, SLC41A1, sPLA2, Stat1, stefin A3, SULT2A5, TNFα-IP 8, TSSC3, TTP, TXA synthase, Wnt-16, and xCT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indomethacin, 1 g | sc-200503 | 1 g | $28.00 | |||
Indomethacin, 5 g | sc-200503A | 5 g | $37.00 |