Indolicidin (CAS 140896-21-5)

Indolicidin, a naturally occurring antimicrobial peptide, has garnered significant interest in scientific research due to its unique mechanism of action and potential applications in various fields. Recent studies have explaind its mechanism of action, revealing its ability to disrupt bacterial cell membranes through interactions with anionic phospholipids, such as phosphatidylglycerol and cardiolipin. Indolicidin inserts itself into the lipid bilayer of bacterial membranes, leading to membrane destabilization and permeabilization. This disruption results in leakage of intracellular contents and eventual cell death. Moreover, indolicidin exhibits broad-spectrum antimicrobial activity against a wide range of bacterial pathogens, including both Gram-positive and Gram-negative species. Beyond its antimicrobial properties, indolicidin has been investigated for its immunomodulatory effects, including the modulation of cytokine production and enhancement of host immune responses. Furthermore, researchers have explored its potential applications in biotechnology and materials science, utilizing its antimicrobial properties for the development of antimicrobial coatings, wound dressings, and biomedical devices. Additionally, indolicidin′s structural features have prompted interest in peptide engineering, driving efforts to design novel peptides with improved antimicrobial activity and stability. Overall, indolicidin represents a valuable research tool with diverse applications in antimicrobial research, immunology, and materials science, offering insights into membrane biology and potential strategies against antibiotic-resistant pathogens.