Molecular structure of Indole-3-propionic acid, CAS Number: 830-96-6
Indole-3-propionic acid (CAS 830-96-6)
See product citations (3)
Alternate Names:
IPA
Application:
Indole-3-propionic acid is a reactant for preparation of fluorescent analogues of strigolactones
CAS Number:
830-96-6
Purity:
≥98%
Molecular Weight:
189.21
Molecular Formula:
C11H11NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Indole-3-propionic acid is a reactant for preparation of fluorescent analogues of strigolactones, melanocortin receptors ligands, histamine H4 receptor agonists, and NR2B/NMDA receptor antagonists. Indole-3-propionic acid, also known as indolepropionate or b-(3-indolyl)propionic acid, is a bacterial metabolite with remarkable antioxidant and neuroprotective properties. In cell-free assays, it effectively scavenges ABTS radicals at concentrations ranging from 50 to 150 µM. It exhibits the ability to reduce malondialdehyde (MDA) levels in rat striatal membranes induced by hydrogen peroxide, with an IC50 value of 180 µM. Indole-3-propionic acid also counteracts the increase in MDA levels triggered by amyloid β (1-42) in PC12 cells.
Indole-3-propionic acid (CAS 830-96-6) References
- Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. | Zhao, ZH., et al. 2019. Exp Mol Med. 51: 1-14. PMID: 31506421
- Indole-3-propionic Acid Improved the Intestinal Barrier by Enhancing Epithelial Barrier and Mucus Barrier. | Li, J., et al. 2021. J Agric Food Chem. 69: 1487-1495. PMID: 33356219
- Indole-3-Propionic Acid, a Gut-Derived Tryptophan Metabolite, Associates with Hepatic Fibrosis. | Sehgal, R., et al. 2021. Nutrients. 13: PMID: 34684510
- Indole-3-propionic acid, a tryptophan-derived bacterial metabolite, increases blood pressure via cardiac and vascular mechanisms in rats. | Konopelski, P., et al. 2021. Am J Physiol Regul Integr Comp Physiol. 321: R969-R981. PMID: 34755563
- Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation. | Du, L., et al. 2021. Int J Mol Sci. 22: PMID: 34830317
- Indole-3-propionic Acid-aggravated CCl4-induced Liver Fibrosis via the TGF-β1/Smads Signaling Pathway. | Liu, F., et al. 2021. J Clin Transl Hepatol. 9: 917-930. PMID: 34966655
- Indole-3-propionic acid attenuates high glucose induced ER stress response and augments mitochondrial function by modulating PERK-IRE1-ATF4-CHOP signalling in experimental diabetic neuropathy. | Gundu, C., et al. 2022. Arch Physiol Biochem. 1-14. PMID: 35015592
- Indole-3-propionic acid alleviates ischemic brain injury in a mouse middle cerebral artery occlusion model. | Xie, Y., et al. 2022. Exp Neurol. 353: 114081. PMID: 35405119
- Gut Flora Mediates the Rapid Tolerance of Electroacupuncture on Ischemic Stroke by Activating Melatonin Receptor through Regulating Indole-3-Propionic Acid. | Li, S., et al. 2022. Am J Chin Med. 50: 979-1006. PMID: 35475976
- Indole-3-Propionic Acid as a Potential Therapeutic Agent for Sepsis-Induced Gut Microbiota Disturbance. | Fang, H., et al. 2022. Microbiol Spectr. 10: e0012522. PMID: 35658593
- Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease. | Xue, H., et al. 2022. Circ Res. 131: 404-420. PMID: 35893593
- Indole-3-propionic Acid Attenuates HI-Related Blood-Brain Barrier Injury in Neonatal Rats by Modulating the PXR Signaling Pathway. | Zhao, Q., et al. 2022. ACS Chem Neurosci. 13: 2897-2912. PMID: 36129348
- Gut microbiota-derived indole 3-propionic acid partially activates aryl hydrocarbon receptor to promote macrophage phagocytosis and attenuate septic injury. | Huang, ZB., et al. 2022. Front Cell Infect Microbiol. 12: 1015386. PMID: 36299625
- Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis. | Zhuang, H., et al. 2023. Mol Med. 29: 17. PMID: 36721094
- Indole-3-propionic acid alleviates sepsis-associated acute liver injury by activating pregnane X receptor. | Wang, S., et al. 2023. Mol Med. 29: 65. PMID: 37208586
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indole-3-propionic acid, 25 g | sc-255215 | 25 g | $166.00 |