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Indole-3-carbinol (CAS 700-06-1)

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Alternate Names:
3-Indolemethanol
Application:
Indole-3-carbinol is a cell growth inhibitor
CAS Number:
700-06-1
Purity:
≥96%
Molecular Weight:
147.17
Molecular Formula:
C9H9NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Indole-3-carbinol is a cell growth inhibitor that reversibly suppresses incorporation of [3H]thymidine in cells. This agent has been reported to induce G1 cell cycle arrest and block the expression of cyclin-dependent kinase 6. Additionally, Indole-3-carbinol displays the ability to inhibit endogenous retinoblastoma protein phosphorylation. Mechanistic studies suggest that in vitro this compound inhibits cell adhesion, migration, and invasion.


Indole-3-carbinol (CAS 700-06-1) References

  1. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.  |  Meng, Q., et al. 2000. J Mol Med (Berl). 78: 155-65. PMID: 10868478
  2. Indole-3-carbinol (I3C) as Leukemia Therapeutic Agents: Review.  |  Karimabad, MN., et al. 2023. Mini Rev Med Chem. 23: 150-158. PMID: 35339173
  3. A microplate spectrophotometric method for analysis of indole-3-carbinol in dietary supplements using p-dimethylaminocinnamaldehyde (DMACA) as a chromogenic reagent.  |  Chaisiwamongkhol, K., et al. 2022. Anal Methods. 14: 3366-3374. PMID: 36039897
  4. Indole-3-carbinol ameliorated the neurodevelopmental deficits in neonatal anoxic injury in rats.  |  Ramakrishna, K. and Krishnamurthy, S. 2023. Int J Dev Neurosci. 83: 31-43. PMID: 36259087
  5. Indole-3-carbinol induces apoptosis in AGS cancer cells via mitochondrial pathway.  |  Singh, AA., et al. 2023. Chem Biol Drug Des. 101: 1367-1381. PMID: 36798994
  6. Indole-3-Carbinol: Occurrence, Health-Beneficial Properties, and Cellular/Molecular Mechanisms.  |  Amarakoon, D., et al. 2023. Annu Rev Food Sci Technol. 14: 347-366. PMID: 36972159
  7. Maximizing the value of indole-3-carbinol, from its distribution in dietary sources, health effects, metabolism, extraction, and analysis in food and biofluids.  |  Nagia, M., et al. 2023. Crit Rev Food Sci Nutr. 1-22. PMID: 37051943
  8. Indole-3-carbinol mitigates oxidative stress and inhibits inflammation in rat cerebral ischemia/reperfusion model.  |  Chichai, AS., et al. 2023. Biochimie. 213: 1-11. PMID: 37120006
  9. Indole-3-carbinol ameliorated the thioacetamide-induced hepatic encephalopathy in rats.  |  Ramakrishna, K., et al. 2023. Toxicology. 492: 153542. PMID: 37150287
  10. Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models.  |  Pennarossa, G., et al. 2023. Phytochemistry. 212: 113713. PMID: 37169138
  11. Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles.  |  Wattenberg, LW. and Loub, WD. 1978. Cancer Res. 38: 1410-3. PMID: 416908
  12. Indole-3-carbinol. A novel approach to breast cancer prevention.  |  Bradlow, HL., et al. 1995. Ann N Y Acad Sci. 768: 180-200. PMID: 8526347
  13. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.  |  Cover, CM., et al. 1998. J Biol Chem. 273: 3838-47. PMID: 9461564

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Indole-3-carbinol, 1 g

sc-202662
1 g
$38.00

Indole-3-carbinol, 5 g

sc-202662A
5 g
$60.00

Indole-3-carbinol, 100 g

sc-202662B
100 g
$143.00

Indole-3-carbinol, 250 g

sc-202662C
250 g
$306.00

Indole-3-carbinol, 1 kg

sc-202662D
1 kg
$1012.00