Molecular structure of Indirubin-3′-monoxime-5-sulphonic Acid, CAS Number: 331467-05-1
Indirubin-3′-monoxime-5-sulphonic Acid (CAS 331467-05-1)
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Application:
Indirubin-3′-monoxime-5-sulphonic Acid is an inhibitor of GSK-3β, Cdc2 (Cdk1) and Cdk5.
CAS Number:
331467-05-1
Purity:
≥97%
Molecular Weight:
357.3
Molecular Formula:
C16H11N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A potent inhibitor of Cdk1 and Cdk5 and glycogen synthase kinase-3β. The inhibition is competitive with respect to ATP.
Indirubin-3′-monoxime-5-sulphonic Acid (CAS 331467-05-1) References
- Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? | Leclerc, S., et al. 2001. J Biol Chem. 276: 251-60. PMID: 11013232
- Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors. | Bertrand, JA., et al. 2003. J Mol Biol. 333: 393-407. PMID: 14529625
- RhoB enhances migration and MMP1 expression of prostate cancer DU145. | Yoneda, M., et al. 2010. Exp Mol Pathol. 88: 90-5. PMID: 19782069
- Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3. | Ojo, KK., et al. 2011. Mol Biochem Parasitol. 176: 98-108. PMID: 21195115
- Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16. | Dixon-Clarke, SE., et al. 2017. Biochem J. 474: 699-713. PMID: 28057719
- Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice. | Chen, L., et al. 2017. Front Mol Neurosci. 10: 393. PMID: 29234273
- Construction and Comprehensive Analysis of Dysregulated Long Noncoding RNA-Associated Competing Endogenous RNA Network in Moyamoya Disease. | Gu, X., et al. 2020. Comput Math Methods Med. 2020: 2018214. PMID: 32617116
- Naphthoquinone as a New Chemical Scaffold for Leishmanicidal Inhibitors of Leishmania GSK-3. | Sebastián-Pérez, V., et al. 2022. Biomedicines. 10: PMID: 35625873
- Anti-inflammatory Effect of Indirubin-3'-Monoxime-5-Sulphonic Acid on Lipopolysaccharide-stimulated Murine Macrophage[J]. | Kim H J, Heo H S, Park G M,., 2011. J. Exp. Biomed. Sci., 17(3):: 225-230.
Inhibitor of:
Cdc2, Cdk, and Cdk5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indirubin-3'-monoxime-5-sulphonic Acid, 1 mg | sc-221753 | 1 mg | $183.00 |