Molecular structure of Indibulin, CAS Number: 204205-90-3
Indibulin (CAS 204205-90-3)
Alternate Names:
D-24851
Application:
Indibulin is a microtubule destabilizer
CAS Number:
204205-90-3
Molecular Weight:
389.83
Molecular Formula:
C22H16ClN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A microtubule destabilizer that blocks tubulin polymerization (IC50 = 0.3 μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignancies in vitro (IC50 values ranging from 0.036-0.285 μM). Has been shown to induce complete tumor remission in the Yoshida AH13 rat sarcoma model in vivo. Lacks neurotoxicity due to an ability to discriminate between posttranslationally modified tubulin in mature neuronal microtubules and less-modified tubulin present in immature neuronal or nonneuronal microtubules. Also displays oral availability and efficacy towards MDR tumor cells.
Indibulin (CAS 204205-90-3) References
- D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. | Bacher, G., et al. 2001. Cancer Res. 61: 392-9. PMID: 11196193
- Microtubule inhibitor D-24851 induces p53-independent apoptotic cell death in malignant glioma cells through Bcl-2 phosphorylation and Bax translocation. | Ito, H., et al. 2005. Int J Oncol. 26: 589-96. PMID: 15703812
- Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives. | Yu, PF., et al. 2008. Chem Pharm Bull (Tokyo). 56: 831-4. PMID: 18520089
- Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulin. | Wienecke, A. and Bacher, G. 2009. Cancer Res. 69: 171-7. PMID: 19118000
- Indibulin dampens microtubule dynamics and produces synergistic antiproliferative effect with vinblastine in MCF-7 cells: Implications in cancer chemotherapy. | Kapoor, S., et al. 2018. Sci Rep. 8: 12363. PMID: 30120268
- Synthesis and anti-breast cancer activity of novel indibulin related diarylpyrrole derivatives. | Saeedian Moghadam, E., et al. 2019. Daru. 27: 179-189. PMID: 30891679
- Photorelease of Pyridines Using a Metal-Free Photoremovable Protecting Group. | Tang, XJ., et al. 2020. Angew Chem Int Ed Engl. 59: 18386-18389. PMID: 32671906
- From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin. | Copmans, D., et al. 2022. Pharmaceuticals (Basel). 15: PMID: 35215359
- BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways. | Leu, JD., et al. 2022. Int J Mol Sci. 23: PMID: 36430560
- β-III Tubulin Levels Determine the Neurotoxicity Induced by Colchicine-Site Binding Agent Indibulin. | Kumari, A., et al. 2023. ACS Chem Neurosci. 14: 19-34. PMID: 36541944
Inhibitor of:
Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indibulin, 10 mg | sc-295179 | 10 mg | $145.00 | |||
Indibulin, 50 mg | sc-295179A | 50 mg | $829.00 |