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Molecular structure of Indeno[1,2,3-cd]pyrene, CAS Number: 193-39-5
Indeno[1,2,3-cd]pyrene (CAS 193-39-5)
Alternate Names:
o-Phenylenepyrene; 1,10-(1,2-Phenylene)pyrene
Application:
Indeno[1,2,3-cd]pyrene is a polycyclic aromatic hydrocarbon for oncology research
CAS Number:
193-39-5
Molecular Weight:
276.33
Molecular Formula:
C22H12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon (PAH), prominently exists as a constituent of diesel exhaust and pervades the environment as a consequence of fossil fuel combustion. This compound is recognized as one of the most hazardous PAHs, warranting its classification as a human carcinogen. The mechanism by which Indeno[1,2,3-cd]pyrene operates is not yet comprehensively elucidated. However, current knowledge suggests its interaction with DNA, leading to genetic mutations. It is postulated that the compound binds to DNA, thereby inducing mutations in the genetic code. Additionally, Indeno[1,2,3-cd]pyrene has demonstrated its ability to induce oxidative damage to cells, culminating in cell death.
Indeno[1,2,3-cd]pyrene (CAS 193-39-5) References
- Personal exposure to atmospheric polycyclic aromatic hydrocarbons in a general adult population and lung cancer risk assessment. | Zmirou, D., et al. 2000. J Occup Environ Med. 42: 121-6. PMID: 10693071
- Enhanced biodegradation of pyrene and indeno(1,2,3-cd)pyrene using bacteria immobilized in cinder beads in estuarine wetlands. | Huang, RY., et al. 2016. Mar Pollut Bull. 102: 128-33. PMID: 26632525
- A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor. | Wong, TH., et al. 2018. Sci Rep. 8: 5198. PMID: 29581487
- Enhanced degradation of indeno(1,2,3-cd)pyrene using Candida tropicalis NN4 in presence of iron nanoparticles and produced biosurfactant: a statistical approach. | Ojha, N., et al. 2019. 3 Biotech. 9: 86. PMID: 30800597
- Indeno[1,2,3-cd]pyrene and picene mediate actions via estrogen receptor α signaling pathway in in vitro cell systems, altering gene expression. | Böckers, M., et al. 2020. Toxicol Appl Pharmacol. 396: 114995. PMID: 32251684
- Hydroxylation at Multiple Positions Initiated the Biodegradation of Indeno[1,2,3-cd]Pyrene in Rhodococcus aetherivorans IcdP1. | Miao, LL., et al. 2020. Front Microbiol. 11: 568381. PMID: 33072027
- Multidimensional Analysis of Lung Lymph Nodes in a Mouse Model of Allergic Lung Inflammation following PM2.5 and Indeno[1,2,3-cd]pyrene Exposure. | Liu, KY., et al. 2023. Environ Health Perspect. 131: 37014. PMID: 36975775
- Tumor-initiating activity of major in vivo metabolites of indeno[1,2,3-cd]pyrene on mouse skin. | Rice, JE., et al. 1986. Carcinogenesis. 7: 1761-4. PMID: 3757177
- Identification of mutagenic metabolites of indeno[1,2,3-cd]pyrene formed in vitro with rat liver enzymes. | Rice, JE., et al. 1985. Cancer Res. 45: 5421-5. PMID: 4053016
- Benzo(k)fluoranthene, Benzo(ghi)perylene, and Indeno(1,2,3-cd)pyrene: New Tracers of Automotive Emissions in Receptor Modeling | Antonio H. Miguel & Pedro A. P. Pereira. 1989. Aerosol Science and Technology. 10: 292-295.
- Degradation and Metabolite Profiling of Benz (a) Anthracene, Dibenz (a, h) Anthracene and Indeno [1, 2, 3-cd] Pyrene by Aspergillus terricola | Swapna Guntupalli, V. B. S. C. Thunuguntla, Leela Madhuri Chalasani, C. V. Rao & Jayakumar Singh Bondili. 2019. Polycyclic Aromatic Compounds. 39: 84-92.
- Measurement of low-temperature heat capacity by relaxation technique: Calorimeter performance testing and heat capacity of benzo[b]fluoranthene, benzo[k]fluoranthene, and indeno[1,2,3-cd]pyrene | Tomáš Mahnel a, Václav Pokorný a, Michal Fulem a, David Sedmidubský b, Květoslav Růžička a. 2020. The Journal of Chemical Thermodynamics. 142.
- Standard Thermodynamic Functions from Experimental Heat Capacity Measurements of Two Polycyclic Aromatic Hydrocarbons, Indeno[1,2,3-cd]pyrene and Benzo[ghi]perylene | Maxim I. Lelet*, Elizaveta O. Silyakova, and Julia N. Lelet, et al. 2021. J. Chem. Eng. Data. 66: 3735–3744.
Inhibitor of:
polycyclic aromatic hydrocarbons.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Indeno[1,2,3-cd]pyrene, 10 mg | sc-257601 | 10 mg | $204.00 |