Date published: 2025-12-4

1-800-457-3801

SCBT Portrait Logo
Seach Input

Indanomycin (CAS 66513-28-8)

0.0(0)
Write a reviewAsk a question

Application:
Indanomycin is an unusual pyrollic ionophore active against Gram +ve bacteria and insects
CAS Number:
66513-28-8
Molecular Weight:
493.7
Molecular Formula:
C31H43NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Indanomycin is a compound that functions as an inhibitor of RNA polymerase. It exerts its mechanism of action by binding to the enzyme and preventing the elongation of RNA chains during transcription. This interference with the transcription process ultimately leads to the inhibition of protein synthesis. Indanomycin targets the active site of RNA polymerase, disrupting its ability to catalyze the formation of RNA molecules. Indanomycin′s mechanism of action involves the disruption of the normal functioning of RNA polymerase at the molecular level, thereby affecting gene expression and cellular processes.


Indanomycin (CAS 66513-28-8) References

  1. Biosynthetic origins of the ionophore antibiotic indanomycin.  |  Roege, KE. and Kelly, WL. 2009. Org Lett. 11: 297-300. PMID: 19072095
  2. Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.  |  Li, C., et al. 2009. Chembiochem. 10: 1064-72. PMID: 19301315
  3. Identification of a tetraene-containing product of the indanomycin biosynthetic pathway.  |  Rommel, KR., et al. 2011. Org Lett. 13: 2536-9. PMID: 21491871
  4. Syntheses of the hexahydroindene cores of indanomycin and stawamycin by combinations of iridium-catalyzed asymmetric allylic alkylations and intramolecular Diels-Alder reactions.  |  Gärtner, M., et al. 2013. Chemistry. 19: 400-5. PMID: 23180592
  5. Indanomycin-related antibiotics from marine Streptomyces antibioticus PTZ0016.  |  Lian, XY. and Zhang, Z. 2013. Nat Prod Res. 27: 2161-7. PMID: 23639115
  6. Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.  |  Luhavaya, H., et al. 2015. Angew Chem Int Ed Engl. 54: 13622-5. PMID: 26377145
  7. The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.  |  Keatinge-Clay, AT. 2017. Chem Rev. 117: 5334-5366. PMID: 28394118
  8. Zincophorin - biosynthesis in Streptomyces griseus and antibiotic properties.  |  Walther, E., et al. 2016. GMS Infect Dis. 4: Doc08. PMID: 30671322
  9. Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters.  |  Del Carratore, F., et al. 2019. Commun Biol. 2: 83. PMID: 30854475
  10. Ionophore antibiotic X-206 is a potent inhibitor of SARS-CoV-2 infection in vitro.  |  Svenningsen, EB., et al. 2021. Antiviral Res. 185: 104988. PMID: 33248195
  11. Macrophage-targeting oligopeptides from Mortierella alpina.  |  Wurlitzer, JM., et al. 2022. Chem Sci. 13: 9091-9101. PMID: 36091214
  12. Comparative and Functional Analyses Reveal Conserved and Variable Regulatory Systems That Control Lasalocid Biosynthesis in Different Streptomyces Species.  |  Liu, M., et al. 2023. Microbiol Spectr. 11: e0385222. PMID: 36847561
  13. Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase.  |  Englund, E., et al. 2023. J Am Chem Soc. 145: 8822-8832. PMID: 37057992

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Indanomycin, 1 mg

sc-362025
1 mg
$299.00