Molecular structure of IN-1130, CAS Number: 868612-83-3
IN-1130 (CAS 868612-83-3)
Alternate Names:
IN 1130 Benzamide, 3-((4-(6-methyl-2-pyridinyl)-5-(6-quinoxalinyl)-1H-imidazol-2-yl)methyl)- IN1130
CAS Number:
868612-83-3
Molecular Weight:
420.50
Molecular Formula:
C25H20N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
IN-1130 (CAS 868612-83-3) References
- IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. | Moon, JA., et al. 2006. Kidney Int. 70: 1234-43. PMID: 16929250
- Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. | Luo, J., et al. 2007. J Clin Invest. 117: 3306-15. PMID: 17965773
- Pharmacokinetics and tissue distribution of 3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzamide; a novel ALK5 inhibitor and a potential anti-fibrosis drug. | Kim, YW., et al. 2008. Xenobiotica. 38: 325-39. PMID: 18274960
- Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor. | Kim, YW., et al. 2008. Xenobiotica. 38: 451-64. PMID: 18421620
- Effect of IN-1130, a small molecule inhibitor of transforming growth factor-beta type I receptor/activin receptor-like kinase-5, on prostate cancer cells. | Lee, GT., et al. 2008. J Urol. 180: 2660-7. PMID: 18951571
- IN-1130, a novel transforming growth factor-beta type I receptor kinase (activin receptor-like kinase 5) inhibitor, promotes regression of fibrotic plaque and corrects penile curvature in a rat model of Peyronie's disease. | Ryu, JK., et al. 2009. J Sex Med. 6: 1284-96. PMID: 19473283
- Activin Receptor-Like Kinase 5 Inhibitor Attenuates Fibrosis in Fibroblasts Derived from Peyronie's Plaque. | Jang, JH., et al. 2012. Korean J Urol. 53: 44-9. PMID: 22323974
- Transforming growth factor-β1 receptor inhibition preserves glomerulotubular integrity during ureteral obstruction in adults but worsens injury in neonatal mice. | Galarreta, CI., et al. 2013. Am J Physiol Renal Physiol. 304: F481-90. PMID: 23303407
- An novel inhibitor of TGF-β type I receptor, IN-1130, blocks breast cancer lung metastasis through inhibition of epithelial-mesenchymal transition. | Park, CY., et al. 2014. Cancer Lett. 351: 72-80. PMID: 24887560
- GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury. | Platko, K., et al. 2019. Mol Metab. 27: 62-74. PMID: 31288993
Inhibitor of:
ACTR-IIB, BMP-6, DAF-1, dsg1α, IL-3Rβ, NOMO3, Ski, Smad6, Smad8, TBCK, TGF B3, and TGFβ RIII.Activator of:
ACTR-IIA, dpp, Smad2, and SnoN_SnoN2_SnoA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IN-1130, 25 mg | sc-507462 | 25 mg | $435.00 |