Imperatorin CAS: 482-44-0
MF: C16H14O4
MW: 270.28
A useful furocoumarin and phytochemical.

Imperatorin (CAS 482-44-0)

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Alternate Names: Ammidin; Marmelide; Marmelosin
Application: Imperatorin is a useful furocoumarin and phytochemical
CAS Number: 482-44-0
Molecular Weight: 270.28
Molecular Formula: C16H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.


References

1. Pae, H.O., et al. 2002. Pharmacol. Toxicol. 91: 40-48. PMID: 12193260
2. Sancho, R., et al. 2004. J. Biol. Chem. 279: 37349-37359. PMID: 15218031

Physical State :
Solid
Solubility :
Soluble in DMSO (≥5 mg/ml), methanol, DMF, and water (slightly). Insoluble in ethanol.
Storage :
Store at -20° C
Melting Point :
102° C
Boiling Point :
~448.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
BACE: IC50 = 30.5 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LV1575000
PubChem CID :
Merck Index :
14: 4925
MDL Number :
MFCD00016881
EC Number :
207-581-1
Beilstein Registry :
249728
SMILES :
CC(=CCOC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)C

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Certificate of Analysis

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Imperatorin (CAS 482-44-0)  Product Citations

See how others have used Imperatorin (CAS 482-44-0). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 31173794  Toxicon. 60-66.

Citations 1 to 1 of 1 total
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