Molecular structure of Imperatorin, CAS Number: 482-44-0
Imperatorin (CAS 482-44-0)
See product citations (3)
Alternate Names:
Ammidin; Marmelide; Marmelosin
Application:
Imperatorin is a useful furocoumarin and phytochemical
CAS Number:
482-44-0
Molecular Weight:
270.28
Molecular Formula:
C16H14O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Imperatorin is a furocoumarin present in citrus fruits, which is used in HIV-1 research. Studies indicate that the transcription factor Sp1 is essential in the inhibitory functions of Imperatorin. In addition, Imperatorin inhibits cyclin D1 expression and stops the cell cycle at G1. These studies also suggest that Imperatorin suppresses HIV-1 replication in primary T lymphocytes and transformed cell lines. Furthermore, it has been suggested that the inhibitory effects of Imperatorin on HIV-1 at the transcriptional level can be monitored effectively in HeLa cells. Imperatorin can also cause apoptosis in human promyelocytic leukaemia, HL-60 via the cytochrome c/caspase-9 pathway.
Imperatorin (CAS 482-44-0) References
- Imperatorin, a furanocoumarin from Angelica dahurica (Umbelliferae), induces cytochrome c-dependent apoptosis in human promyelocytic leukaemia, HL-60 Cells. | Pae, HO., et al. 2002. Pharmacol Toxicol. 91: 40-8. PMID: 12193260
- Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway. | Sancho, R., et al. 2004. J Biol Chem. 279: 37349-59. PMID: 15218031
- Imperatorin-pharmacological meaning and analytical clues: profound investigation. | Kozioł, E. and Skalicka-Woźniak, K. 2016. Phytochem Rev. 15: 627-649. PMID: 27453708
- Effects of imperatorin in the cardiovascular system and cancer. | Nasser, MI., et al. 2019. Biomed Pharmacother. 120: 109401. PMID: 31622950
- Imperatorin: A review of its pharmacology, toxicity and pharmacokinetics. | Deng, M., et al. 2020. Eur J Pharmacol. 879: 173124. PMID: 32339515
- Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway. | Hassanein, EHM., et al. 2020. Oxid Med Cell Longev. 2020: 1675957. PMID: 32377290
- Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2-ERK Signaling to Suppress Esophageal Cancer Metastasis. | Xu, WW., et al. 2020. Adv Sci (Weinh). 7: 2000925. PMID: 32832354
- Imperatorin alleviated endometriosis by inhibiting the activation of PI3K/Akt/NF-κB pathway in rats. | Ma, T., et al. 2021. Life Sci. 274: 119291. PMID: 33667515
- Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats. | Huang, Y., et al. 2021. Sci Rep. 11: 8590. PMID: 33883654
- Imperatorin attenuates cardiac remodelling and dysfunction in high-fat/high-fructose diet-fed rats by modulating oxidative stress, inflammation, and Nrf-2 expression. | Prasartthong, P., et al. 2022. Tissue Cell. 75: 101728. PMID: 34998165
- Imperatorin Influences Depressive-like Behaviors: A Preclinical Study on Behavioral and Neurochemical Sex Differences. | Kowalczyk, J., et al. 2022. Molecules. 27: PMID: 35208969
- Synthetic imperatorin derivatives alleviate allergic reactions via mast cells. | Wang, C., et al. 2022. Biomed Pharmacother. 150: 112982. PMID: 35483187
- Imperatorin Positively Regulates Melanogenesis through Signaling Pathways Involving PKA/CREB, ERK, AKT, and GSK3β/β-Catenin. | Kim, T. and Hyun, CG. 2022. Molecules. 27: PMID: 36235048
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Imperatorin, 5 mg | sc-218594 | 5 mg | $194.00 | |||
Imperatorin, 50 mg | sc-218594A | 50 mg | $203.00 |