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Impentamine dihydrobromide is a selective H3 receptor antagonist. This compound displays >30000-fold selectivity over H1 and H2 receptors. In SK-N-MC cells expressing human H3 receptors, this can act as a partial agonist. Impentamine dihydrobromide also displays antinociceptive properties, possibly via a non-H1 -H2 or -H3 receptor-mediated mechanism.
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