Molecular structure of Imipramine hydrochloride, CAS Number: 113-52-0
Imipramine hydrochloride (CAS 113-52-0)
See product citations (5)
Alternate Names:
Tofranil; Chrytemin
Application:
Imipramine hydrochloride is an inhibitor of serotonin and norepinephrine transporters
CAS Number:
113-52-0
Purity:
≥98%
Molecular Weight:
316.87
Molecular Formula:
C19H24N2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Imipramine hydrochloride is the hydrochloride salt form of imipramine, a compound with surface-active properties. It acts as a potent inhibitor of serotonin and norepinephrine reuptake, making it effective in increasing the levels of these neurotransmitters. Imipramine hydrochloride exhibits a higher affinity for serotonin, leading to its pronounced anticholinergic side effects. The profile of imipramine hydrochloride involves blocking various receptors, including D-2 receptors, H1 receptors, alpha 1 and alpha 2 adrenergic receptors, and muscarinic receptors. By interfering with these receptor systems, imipramine hydrochloride exerts its effects.
Imipramine hydrochloride (CAS 113-52-0) References
- Imipramine hydrochloride and desipramine hydrochloride as new reagents for detection of microamounts of blood in urine. | Syed, AA., et al. 2002. J Pharm Biomed Anal. 28: 501-7. PMID: 12008129
- Effect of temperature on imipramine hydrochloride permeation: role of lipid bilayer arrangement and chemical composition of rat skin. | Jain, AK. and Panchagnula, R. 2003. Int J Pharm. 250: 287-93. PMID: 12480294
- Imipramine effect on hypothalamic-pituitary-adrenal axis response to hypoglycemia. | Kathol, RG., et al. 1992. Psychiatry Res. 41: 45-52. PMID: 1313983
- Transdermal delivery of imipramine hydrochloride: development and evaluation (in vitro and in vivo) of reservoir gel formulation. | Jain, AK. and Panchagnula, R. 2005. Biopharm Drug Dispos. 26: 41-9. PMID: 15614831
- Light scattering studies of amphiphilic drugs promethazine hydrochloride and imipramine hydrochloride in aqueous electrolyte solutions. | Alam, MS., et al. 2008. J Phys Chem B. 112: 12962-7. PMID: 18808093
- A spectrophotometric assay method for vanadium in biological and environmental samples using 2,4-dinitrophenylhydrazine with imipramine hydrochloride. | Al-Tayar, NG., et al. 2012. Environ Monit Assess. 184: 181-91. PMID: 21625927
- Imipramine hydrochloride: pharmacodynamic effects on lower urinary tract of female dogs. | Khanna, OP., et al. 1975. Urology. 6: 49-51. PMID: 238322
- Drug interactions between imipramine and benzodiazepines in rats. | Okiyama, M., et al. 1988. J Pharm Sci. 77: 56-63. PMID: 2894451
- The evaluation of effect of selected metal ions on the efficiency of passive and active transport of imipramine. | Opoka, W., et al. 2019. Psychiatr Pol. 53: 1169-1179. PMID: 31955193
- Imipramine in prepubertal major depressive disorders. | Puig-Antich, J., et al. 1987. Arch Gen Psychiatry. 44: 81-9. PMID: 3541830
- Imipramine-induced erection, masturbation, and ejaculation in male horses. | McDonnell, SM., et al. 1987. Pharmacol Biochem Behav. 27: 187-91. PMID: 3615542
- The influence of an experimental liver cirrhosis upon the metabolism of diazepam and imipramine hydrochloride in the rat. | Trennery, PN. and Waring, RH. 1985. Xenobiotica. 15: 813-23. PMID: 4072248
- A sensitive colorimetric method for the determination of imipramine hydrochloride and desipramine hydrochloride. | el-Yazbi, FA., et al. 1985. J Clin Hosp Pharm. 10: 373-7. PMID: 4093508
- The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations. | Giardina, EG., et al. 1979. Circulation. 60: 1045-52. PMID: 487538
Inhibitor of:
Alk-SMase, CHMP2, CLPTM1L, FMO4, GLTPD1, GM2-AP, KCNH5, LAL, LAMP-5, LIMP II, LPAAT-γ, N-SMase3, NAT-15, Olfr95, Olfr958, PCP-4, Serotonin, SLC6A2, and TIP47.Activator of:
Flavivirus, FMO5, O-Ac GD3, and p22-phox.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Imipramine hydrochloride, 100 mg | sc-207753 | 100 mg | $25.00 | |||
Imipramine hydrochloride, 1 g | sc-207753B | 1 g | $44.00 | |||
Imipramine hydrochloride, 5 g | sc-207753A | 5 g | $101.00 |