Molecular structure of Imipramine-d6, CAS Number: 65100-45-0
Imipramine-d6 (CAS 65100-45-0)
Alternate Names:
10,11-Dihydro-N,N-di(methyl-d3)-5H-dibenz[b,f]azepine-5-propanamine
Application:
Imipramine-d6 is an inhibitor of ST and SLC6A2, but not the dopamine transporter
CAS Number:
65100-45-0
Molecular Weight:
286.44
Molecular Formula:
C19H18D6N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A labeled tricyclic antidepressant that inhibits the serotonin and norepinephrine transporters and has little effect on the dopamine transporter.
Imipramine-d6 (CAS 65100-45-0) References
- Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. | Okugawa, G., et al. 1999. J Neuroendocrinol. 11: 887-95. PMID: 10520140
- Plasma membrane monoamine transporters: structure, regulation and function. | Torres, GE., et al. 2003. Nat Rev Neurosci. 4: 13-25. PMID: 12511858
- CLINICAL PHARMACOLOGY OF IMIPRAMINE AND RELATED ANTIDEPRESSANT COMPOUNDS. | KLERMAN, GL. and COLE, JO. 1965. Pharmacol Rev. 17: 101-41. PMID: 14294030
- Simultaneous determination of 5 psychotropic drugs of various types in an autopsy case of acute multiple drug poisoning. | Sasaki, C., et al. 2013. Forensic Sci Int. 227: 90-4. PMID: 23266306
- A pilot study of the mechanism of action of desipramine. | Checkley, SA., et al. 1981. Br J Psychiatry. 138: 248-51. PMID: 6268238
- Down-regulation of the human norepinephrine transporter in intact 293-hNET cells exposed to desipramine. | Zhu, MY., et al. 1998. J Neurochem. 70: 1547-55. PMID: 9523572
- The synthesis of N‐deuteromethylated desipramine and imipramine | Shaw, G. J., & Markey, S. P. 1977. Journal of Labelled Compounds and Radiopharmaceuticals. 13(3): 315-322.
- Nonmembrane amperometric sensor for dissolved oxygen in flow-through systems | Wolff, C. M., & Mottola, H. A. 1977. Analytical Chemistry. 49(13): 2118-2121.
Inhibitor of:
mAChR M2, SLC6A2, SR-2A, SR-2C, and ST.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Imipramine-d6, 2.5 mg | sc-207754 | 2.5 mg | $290.00 |