Date published: 2025-9-9

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Imidocarb dipropionate (CAS 55750-06-6)

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CAS Number:
55750-06-6
Purity:
≥99%
Molecular Weight:
496.56
Molecular Formula:
C25H32N6O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Imidocarb dipropionate is an organophosphate-based compound extensively used in research on protozoal infections caused by parasites like Babesia, Theileria, and Ehrlichia. Additionally, it is investigated in relation to select bacterial and fungal infections. Imidocarb dipropionate exhibits long-acting properties and a broad spectrum of activity against parasites. Imidocarb dipropionate has multiple physiological and biochemical effects. One of its mechanisms of action is the inhibition of acetylcholinesterase, an enzyme responsible for the breakdown of acetylcholine, a neurotransmitter involved in nerve impulse transmission. This inhibition results in increased levels of acetylcholine in the body, ultimately leading to the inhibition of nerve impulses. Moreover, it has been observed to inhibit phospholipase A2, resulting in elevated levels of arachidonic acid. Additionally, imidocarb dipropionate inhibits cyclooxygenase, leading to increased levels of prostaglandins. In vitro studies have extensively employed imidocarb dipropionate to examine its effects. It has been utilized to investigate its impact on cell proliferation and metabolism. Furthermore, researchers have explored its influence on the immune system and the nervous system.


Imidocarb dipropionate (CAS 55750-06-6) References

  1. Pharmacokinetics of imidocarb dipropionate in horses after intramuscular administration.  |  Belloli, C., et al. 2002. Equine Vet J. 34: 625-9. PMID: 12358005
  2. Pharmacokinetics and mammary elimination of imidocarb in sheep and goats.  |  Belloli, C., et al. 2006. J Dairy Sci. 89: 2465-72. PMID: 16772563
  3. Failure of imidocarb dipropionate to clear experimentally induced Ehrlichia canis infection in dogs.  |  Eddlestone, SM., et al. 2006. J Vet Intern Med. 20: 840-4. PMID: 16955806
  4. Imidocarb dipropionate clears persistent Babesia caballi infection with elimination of transmission potential.  |  Schwint, ON., et al. 2009. Antimicrob Agents Chemother. 53: 4327-32. PMID: 19620328
  5. Failure of imidocarb dipropionate to eliminate Hepatozoon canis in naturally infected dogs based on parasitological and molecular evaluation methods.  |  Sasanelli, M., et al. 2010. Vet Parasitol. 171: 194-9. PMID: 20444549
  6. Failure of combination therapy with imidocarb dipropionate and toltrazuril to clear Hepatozoon canis infection in dogs.  |  Pasa, S., et al. 2011. Parasitol Res. 109: 919-26. PMID: 21472405
  7. Efficacy of imidocarb dipropionate in eliminating Theileria equi from experimentally infected horses.  |  Grause, JF., et al. 2013. Vet J. 196: 541-6. PMID: 23199699
  8. Comparison of glycopyrrolate and atropine in ameliorating the adverse effects of imidocarb dipropionate in horses.  |  Donnellan, CM., et al. 2013. Equine Vet J. 45: 625-9. PMID: 23461655
  9. Failure of imidocarb dipropionate and toltrazuril/emodepside plus clindamycin in treating Hepatozoon canis infection.  |  De Tommasi, AS., et al. 2014. Vet Parasitol. 200: 242-5. PMID: 24439769
  10. Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor.  |  Hines, SA., et al. 2015. Parasit Vectors. 8: 33. PMID: 25600252
  11. Imidocarb dipropionate in the treatment of Anaplasma marginale in cattle: Effects on enzymes of the antioxidant, cholinergic, and adenosinergic systems.  |  Doyle, RL., et al. 2016. Microb Pathog. 97: 226-30. PMID: 27301742
  12. Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses.  |  Jaramillo, FM., et al. 2020. Vet Rec Open. 7: e000416. PMID: 33178437
  13. Imidocarb Dipropionate Lacks Efficacy against Theileria haneyi and Fails to Consistently Clear Theileria equi in Horses Co-Infected with T. haneyi.  |  Sears, K., et al. 2020. Pathogens. 9: PMID: 33321715
  14. Efficacy of long-acting oxytetracycline and imidocarb dipropionate for the chemosterilization of Anaplasma marginale in experimentally infected carrier cattle in Argentina.  |  Sarli, M., et al. 2021. Vet Parasitol Reg Stud Reports. 23: 100513. PMID: 33678368

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Imidocarb dipropionate, 10 g

sc-250148
10 g
$200.00