ILT-4/5 Antibody (F-7): sc-390287

ILT-4/5 Antibody (F-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects ILT-4/5 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ILT-4/5 antibody (F-7) is available as the non-conjugated form. ILT-4/5 is a member of the leukocyte immunoglobulin-like receptor family, which plays a crucial role in the immune response by modulating the activity of immune cells. ILT-4 and ILT-5 are primarily expressed on monocytes, dendritic cells, and natural killer cells, where these proteins function as inhibitory receptors that help maintain immune tolerance and prevent excessive immune activation. This regulation is particularly important in autoimmune diseases and transplant rejection, as ILT-4/5 can inhibit T cell activation and other immune components. ILT-4 and ILT-5′s interaction with various ligands, including major histocompatibility complex (MHC) molecules, further underscores their significance in immune regulation. Using ILT-4/5 (F-7) monoclonal antibody in research can provide valuable insights into immune modulation mechanisms and potential therapeutic targets for enhancing immune responses in various clinical settings.

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ILT-4/5 Antibody (F-7) References:

1. New nomenclature for MHC receptors.  |  André, P., et al. 2001. Nat Immunol. 2: 661. PMID: 11477395
2. Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G.  |  Shiroishi, M., et al. 2003. Proc Natl Acad Sci U S A. 100: 8856-61. PMID: 12853576
3. Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors.  |  Foster, CE., et al. 2003. J Biol Chem. 278: 46081-6. PMID: 12960161
4. Transcriptional regulation of ILT family receptors.  |  Nakajima, H., et al. 2003. J Immunol. 171: 6611-20. PMID: 14662864
5. Expression of inhibitory receptor ILT3 on neoplastic B cells is associated with lymphoid tissue involvement in chronic lymphocytic leukemia.  |  Colovai, AI., et al. 2007. Cytometry B Clin Cytom. 72: 354-62. PMID: 17266150
6. Co-expression of immunoglobulin-like transcript 4 and angiopoietin-like proteins in human non-small cell lung cancer.  |  Wang, L., et al. 2015. Mol Med Rep. 11: 2789-96. PMID: 25482926
7. Immunoglobulin-Like Transcript 5 Inhibits Macrophage-Mediated Bacterial Killing and Antigen Presentation During Sepsis.  |  Ming, S., et al. 2019. J Infect Dis. 220: 1688-1699. PMID: 31250008
8. First-in-Class Anti-immunoglobulin-like Transcript 4 Myeloid-Specific Antibody MK-4830 Abrogates a PD-1 Resistance Mechanism in Patients with Advanced Solid Tumors.  |  Siu, LL., et al. 2022. Clin Cancer Res. 28: 57-70. PMID: 34598945
9. Tumor-derived immunoglobulin like transcript 5 induces suppressive immunocyte infiltration in colorectal cancer.  |  Shi, W., et al. 2022. Cancer Sci. 113: 1939-1954. PMID: 35377522
10. Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways.  |  Samaridis, J. and Colonna, M. 1997. Eur J Immunol. 27: 660-5. PMID: 9079806
11. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules.  |  Cosman, D., et al. 1997. Immunity. 7: 273-82. PMID: 9285411
12. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.  |  Colonna, M., et al. 1997. J Exp Med. 186: 1809-18. PMID: 9382880

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ILT-4/5 Antibody (F-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ILT-4/5 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ILT-4/5 Antibody (F-7) Specifications

Alternate Product Name: ILT-4/5

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 571-601

Epitope Target: ILT-4

Epitope Species: human

Product Reactivity/Detection: ILT-4, ILT-5 and LIR-8

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ILT-4/5 Antibody (F-7): P: Blocking Peptide