Ile-Ile-OH (CAS 42537-99-5)
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Trifluoroacetic acid (TFA) is a potent acid used extensively for detaching synthesized peptides from solid-phase resins. It is also employed to enhance the performance of high-performance liquid chromatography (HPLC) during the peptide purification process. Typically, custom peptides are supplied as lyophilized TFA salts, containing TFA concentrations ranging from 10-45%. The presence of TFA in custom peptides can lead to unexplained inconsistencies in subsequent assay results. For example, even at nanomolar concentrations, TFA has been observed to disrupt cellular assays, causing inhibition of cellular proliferation in certain cases while increasing cell viability in others. Additionally, TFA has unintentionally been identified as an allosteric modulator of the glycine receptor, GlyR.
Ile-Ile-OH (CAS 42537-99-5) References
- A crystallographic titration of the dipeptide L-isoleucyl-L-isoleucine. | Görbitz, CH. 2004. Acta Crystallogr B. 60: 569-77. PMID: 15367792
- Mechanism and Regulation of Isoleucine Excretion in Corynebacterium glutamicum. | Hermann, T. and Kramer, R. 1996. Appl Environ Microbiol. 62: 3238-44. PMID: 16535397
- Piriformospora indica Stimulates Root Metabolism of Arabidopsis thaliana. | Strehmel, N., et al. 2016. Int J Mol Sci. 17: PMID: 27399695
- Compounds which serve as the sole source of carbon or nitrogen for Salmonella typhimurium LT-2. | Gutnick, D., et al. 1969. J Bacteriol. 100: 215-9. PMID: 4898986
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ile-Ile-OH, 250 mg | sc-471440 | 250 mg | $98.00 |