IL-4Rα Antibody (G-9): sc-137256

IL-4Rα Antibody (G-9) is a mouse monoclonal IgG1 antibody that detects IL-4Rα in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-4Rα, or interleukin-4 receptor alpha, plays a crucial role in the immune response by serving as a high-affinity receptor for interleukin-4 (IL-4), a key cytokine involved in the differentiation of T helper cells. IL-4Rα (G-9) antibody recognizes IL-4Rα on the surface of immune cells, which is essential for mediating IL-4 effects, including promoting B cell growth and differentiation and influencing T cell polarization towards a Th2 phenotype. This polarization is particularly important in allergic responses and asthma, as IL-4Rα drives immunoglobulin E (IgE) production and enhances eosinophil activity. IL-4Rα monoclonal antibody (G-9) helps researchers study IL-4Rα′s role in various pathological conditions, including autoimmune diseases and certain cancers, making anti-IL-4Rα antibody (G-9) a valuable tool for exploring therapeutic potential in IL-4 signaling pathways.

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IL-4Rα Antibody (G-9) References:

1. Role of IL-4Rα during acute schistosomiasis in mice.  |  Ndlovu, H. and Brombacher, F. 2014. Parasite Immunol. 36: 421-7. PMID: 24127774
2. IL-4Rα, a STUB-strate for proteasomal degradation: understanding the termination of cytokine signaling in asthma.  |  Yadava, K. and Marsland, BJ. 2014. Am J Respir Crit Care Med. 189: 4-6. PMID: 24381986
3. IL-4Rα Inhibitor for Atopic Disease.  |  Chang, HY. and Nadeau, KC. 2017. Cell. 170: 222. PMID: 28708993
4. Chronic rhinosinusitis with nasal polyps: mechanistic insights from targeting IL-4 and IL-13 via IL-4Rα inhibition with dupilumab.  |  Kariyawasam, HH. 2020. Expert Rev Clin Immunol. 16: 1115-1125. PMID: 33148074
5. Tralokinumab Effectively Disrupts the IL-13/IL-13Rα1/IL-4Rα Signaling Complex but Not the IL-13/IL-13Rα2 Complex.  |  Tollenaere, MAX., et al. 2023. JID Innov. 3: 100214. PMID: 37554517
6. Type 2 cytokines promote angiogenesis in ischemic muscle via endothelial IL-4Rα signaling.  |  Li, H., et al. 2023. Cell Rep. 42: 112964. PMID: 37556326
7. Th2 cytokine signaling through IL-4Rα increases eotaxin-3 secretion and tension in human esophageal smooth muscle.  |  Nelson, MR., et al. 2024. Am J Physiol Gastrointest Liver Physiol. 326: G38-G52. PMID: 37933466
8. Efficacy and safety of rademikibart (CBP-201), a next-generation mAb targeting IL-4Rα, in adults with moderate to severe atopic dermatitis: A phase 2 randomized trial (CBP-201-WW001).  |  Silverberg, JI., et al. 2024. J Allergy Clin Immunol. 153: 1040-1049.e12. PMID: 38157942
9. IL-4Rα signaling promotes barrier-altering oncostatin M and IL-6 production in aspirin-exacerbated respiratory disease.  |  Chen, CC., et al. 2024. J Allergy Clin Immunol. 154: 458-467.e3. PMID: 38704098
10. Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor.  |  Boomer, J., et al. 2024. Am J Respir Crit Care Med. 210: 1409-1420. PMID: 38935626

The preferred IL-4Rα antibody is IL-4Rα Antibody (H-4): sc-28361.