IL-23R Antibody (3D7): sc-293485

IL-23R Antibody (3D7) is a mouse monoclonal IgG2a kappa light chain antibody that detects IL-23R protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-23R antibody (3D7) is available as a non-conjugated format. IL-23R plays a crucial role in immune response by mediating the effects of cytokine IL-23, which is essential for the differentiation and maintenance of T helper 17 (Th17) cells. Th17 cells are pivotal in defense against extracellular pathogens and are implicated in various autoimmune diseases. IL-23 interaction with IL-23R promotes production of pro-inflammatory cytokines, influencing inflammatory response. Dysregulation of IL-23 signaling has been linked to chronic inflammatory conditions, making IL-23R a potential therapeutic target for treating diseases such as psoriasis and inflammatory bowel disease. IL-23R gene exhibits alternative splicing, resulting in multiple isoforms that may have distinct functions and regulatory mechanisms, further underscoring IL-23R importance in both health and disease.

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IL-23R Antibody (3D7) References:

1. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.  |  Oppmann, B., et al. 2000. Immunity. 13: 715-25. PMID: 11114383
2. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.  |  Wiekowski, MT., et al. 2001. J Immunol. 166: 7563-70. PMID: 11390512
3. IL-23: a cytokine that acts on memory T cells.  |  Frucht, DM. 2002. Sci STKE. 2002: pe1. PMID: 11784889
4. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present.  |  Cooper, AM., et al. 2002. J Immunol. 168: 1322-7. PMID: 11801672
5. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.  |  Watford, WT., et al. 2004. Immunol Rev. 202: 139-56. PMID: 15546391
6. IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human.  |  Vanden Eijnden, S., et al. 2005. Eur J Immunol. 35: 469-75. PMID: 15682457
7. Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells.  |  Zhang, XY., et al. 2006. Immunogenetics. 57: 934-43. PMID: 16372191
8. IL-23R mutation is associated with ulcerative colitis: A systemic review and meta-analysis.  |  Peng, LL., et al. 2017. Oncotarget. 8: 4849-4863. PMID: 27902482
9. IL-23R gene polymorphisms in rheumatoid arthritis.  |  Soysal, E., et al. 2022. Rheumatol Int. 42: 555-562. PMID: 33978821
10. IL-23/IL-23R Promote Macrophage Pyroptosis and T Helper 1/T Helper 17 Cell Differentiation in Mycobacterial Infection.  |  Wang, C., et al. 2023. J Invest Dermatol. 143: 2264-2274.e18. PMID: 37187409
11. IL-23R-Specific Chimeric Antigen Receptor Tregs in Crohn's Disease: Dawn of a Cellular Immunotherapeutic Era?  |  Atreya, R. and Neurath, MF. 2024. J Crohns Colitis.. PMID: 39432833
12. IL-23R is a senescence-linked circulating and tissue biomarker of aging.  |  Carver, CM., et al. 2024. Nat Aging.. PMID: 39658621

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-23R Antibody (3D7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-23R Antibody (3D7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-23R Antibody (3D7) Specifications

Alternate Product Name: IL-23R

Product Clone Name: 3D7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 553-628

Epitope Target: IL-23R

Epitope Species: human

Product Reactivity/Detection: IL-23R

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IL-23R Antibody (3D7): N/A