IL-20 Antibody (PL-C21): sc-134365

IL-20 Antibody (PL-C21) is a mouse monoclonal IgG1 kappa light chain antibody that detects the IL-20 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-20 antibody (PL-C21) is available as a non-conjugated format. IL-20, a member of the interleukin-10 family, is a 53 kDa cytokine that plays a crucial role in regulating inflammatory responses and is particularly important in skin conditions such as psoriasis. IL-20 is primarily secreted by activated T cells and keratinocytes, where IL-20 influences the proliferation and differentiation of various immune cells, thereby contributing to the pathogenesis of inflammatory diseases. IL-20 interaction with receptors on target cells leads to the activation of signaling pathways that promote the expression of pro-inflammatory cytokines, which can exacerbate conditions like psoriasis and atopic dermatitis. Understanding IL-20 function is vital for developing targeted therapies aimed at modulating IL-20 activity in inflammatory diseases, making IL-20 monoclonal antibody (PL-C21) an essential tool for researchers studying these pathways.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IL-20 Antibody (PL-C21) References:

1. Interleukin 20: discovery, receptor identification, and role in epidermal function.  |  Blumberg, H., et al. 2001. Cell. 104: 9-19. PMID: 11163236
2. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10).  |  Gallagher, G., et al. 2000. Genes Immun. 1: 442-50. PMID: 11196675
3. Cytokines: IL-21 joins the gamma(c)-dependent network?  |  Vosshenrich, CA. and Di Santo, JP. 2001. Curr Biol. 11: R175-7. PMID: 11267886
4. Identification of B-cell growth factors (interleukin-14; high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas.  |  Ford, R., et al. 1995. Blood. 86: 283-93. PMID: 7795235
5. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function.  |  Parrish-Novak, J., et al. 2000. Nature. 408: 57-63. PMID: 11081504

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-20 Antibody (PL-C21) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-20 Antibody (PL-C21) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-20 Antibody (PL-C21) Specifications

Alternate Product Name: IL-20

Product Clone Name: PL-C21

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 67-177

Epitope Target: IL-20

Epitope Species: human

Product Reactivity/Detection: IL-20

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for IL-20 Antibody (PL-C21): N/A