IL-2 Antibody (B-10): sc-137119
- IL-2 Antibody (B-10) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 21-153 of IL-2 of human origin
- recommended for detection of IL-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for IL-2 Antibody (B-10) for WB applications. This reagent is now offered in a bundle with IL-2 Antibody (B-10) (see ordering information below).
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IL-2 Antibody (B-10) is a mouse monoclonal IgG2a antibody that detects IL-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-2 plays a crucial role in the immune response by promoting the growth, proliferation, and differentiation of T cells, particularly activated T helper and cytotoxic T cells, which are essential for effective immune defense against pathogens. IL-2′s importance extends beyond T cell activation; serving as a growth factor for B cells, thereby influencing the humoral immune response. IL-2 is primarily secreted by activated helper T cells, which are stimulated through the T cell receptor complex or by various mitogens. Understanding the signaling pathways associated with IL-2, including the c-Fos/c-Jun induction pathway, the c-Myc induction pathway, and the Rapamycin-sensitive pathway, is vital for elucidating IL-2′s role in immune regulation and potential therapeutic applications. Anti-IL-2 antibody (B-10) is an invaluable tool for researchers studying immune responses, T cell biology, and the intricate signaling networks that govern these processes.
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IL-2 Antibody (B-10) References:
- IL-2 flushes out HIV. | Highleyman, L. 1999. BETA. 12: 4. PMID: 11367238
- Alloengraftment in IL-2-treated mice. | Sykes, M. and Pearson, DA. 1992. Bone Marrow Transplant. 10: 157-63. PMID: 1525605
- Activation by IL-2, but not IL-4, up-regulates the expression of the p55 subunit of the IL-2 receptor on IL-2- and IL-4-dependent T cell lines. | Jankovic, DL., et al. 1989. J Immunol. 142: 3113-20. PMID: 2523424
- Two regions within the human IL-2 gene promoter are important for inducible IL-2 expression. | Williams, TM., et al. 1988. J Immunol. 141: 662-6. PMID: 2838551
- T4 cell activation by immobilized phytohemagglutinin: differential capacity to induce IL-2 responsiveness and IL-2 production. | Vine, JB., et al. 1988. J Immunol. 141: 2593-600. PMID: 2844904
- The effect of metals on IL-2-related lymphocyte proliferation. | Warner, GL. and Lawrence, DA. 1988. Int J Immunopharmacol. 10: 629-37. PMID: 3263342
- Transcription and translation dependent induction of interleukin 2 (IL-2) and IL-2 receptors. | Wang, Y., et al. 1984. Immunol Lett. 8: 227-31. PMID: 6437971
- Ligand binding by the IL-2 receptor is modulated by intracellular determinants of the IL-2 receptor beta-chain. | Goldsmith, MA., et al. 1995. J Immunol. 154: 2033-40. PMID: 7868880
- Activation of tumor necrosis factor-alpha production from human neutrophils by IL-2 via IL-2-R beta. | Wei, S., et al. 1993. J Immunol. 150: 1979-87. PMID: 8436829
- Constitutive mRNA and immunoreactivity for IL-2 in human nasal mucosa. | Moss, RB., et al. 1997. Clin Exp Allergy. 27: 406-12. PMID: 9146933
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-2 Antibody (B-10) | sc-137119 | 200 µg/ml | $316.00 | |||
IL-2 Antibody (B-10): m-IgG2a BP-HRP Bundle | sc-546025 | 200 µg Ab; 10 µg BP | $354.00 |