IL-1F9 Antibody (Y-12): sc-80056

IL-1F9 Antibody (Y-12) is a rat monoclonal IgG2a antibody that detects IL-1F9 protein of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-IL-1F9 antibody (Y-12) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important cytokine. IL-1F9, also known as interleukin-1 family member 9 (IL-1εF9), interleukin-1 homolog 1 (IL-1H1), or interleukin-1 ε (IL-1ε), plays a crucial role in immune response by activating IL-1Rrp2 and IL-1RAcP-dependent signaling pathway, which leads to activation of transcription factor NFκB. This activation is vital for promoting host response to injury or infection, highlighting IL-1F9′s significance in inflammatory processes. IL-1F9 is predominantly expressed in tissues such as skin, stomach, lung, and esophagus, where IL-1F9 can influence local immune responses. Additionally, IL-1F9 expression can be modulated by various cytokines, including interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta, as well as by bacterial lipopolysaccharide, indicating IL-1F9′s role in both innate and adaptive immunity. IL-1F9′s ability to interact with other members of IL-1 superfamily, such as IL-1F5, which acts as an antagonist, further underscores IL-1F9′s importance in maintaining immune response balance.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IL-1F9 Antibody (Y-12) References:

1. Four new members expand the interleukin-1 superfamily.  |  Smith, DE., et al. 2000. J Biol Chem. 275: 1169-75. PMID: 10625660
2. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2.  |  Debets, R., et al. 2001. J Immunol. 167: 1440-6. PMID: 11466363
3. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity.  |  Gao, W., et al. 2003. J Immunol. 170: 107-13. PMID: 12496389
4. IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells.  |  Berglöf, E., et al. 2003. J Neuroimmunol. 139: 36-43. PMID: 12799018
5. Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs.  |  Towne, JE., et al. 2004. J Biol Chem. 279: 13677-88. PMID: 14734551
6. Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense.  |  Vos, JB., et al. 2005. Physiol Genomics. 21: 324-36. PMID: 15701729
7. Is IL-1 a good therapeutic target in the treatment of arthritis?  |  Burger, D., et al. 2006. Best Pract Res Clin Rheumatol. 20: 879-96. PMID: 16980212
8. The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders.  |  Barksby, HE., et al. 2007. Clin Exp Immunol. 149: 217-25. PMID: 17590166
9. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex.  |  Chackerian, AA., et al. 2007. J Immunol. 179: 2551-5. PMID: 17675517

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-1F9 Antibody (Y-12) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-1F9 Antibody (Y-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-1F9 Antibody (Y-12) Specifications

Alternate Product Name: IL-1F9

Product Clone Name: Y-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: IL-1F9

Epitope Species: human

Product Reactivity/Detection: IL-1F9

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for IL-1F9 Antibody (Y-12): L: Azide-Free