IL-1 beta/IL1B Antibody (2H12): sc-130323
- IL-1 beta/IL1B Antibody (2H12) is a mouse monoclonal IgG1, cited in 7 publications, provided at 200 µg/ml
- raised against recombinant IL-1β of human origin
- recommended for detection of IL-1β of human origin by IF and IHC(P)
- See IL-1 beta/IL1B (E7-2-hIL1β): sc-32294 for IL-1 beta/IL1B antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-1 beta/IL1B Antibody (2H12). This work is in progress.
IL-1β Antibody (2H12) is a mouse monoclonal IgG1 antibody that detects interleukin-1β (IL-1β) in human samples through immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). IL-1β is a pivotal pro-inflammatory cytokine that plays a crucial role in mediating immune responses and inflammation. IL-1β is primarily produced by activated macrophages and is essential for the activation of T and B lymphocytes, as well as natural killer (NK) cells. Anti-IL-1β antibody (2H12) helps researchers understand how IL-1β stimulates the production of other cytokines, such as interleukin-2, while selectively inhibiting interleukin-4 expression in T cells, thereby influencing the adaptive immune response. Additionally, IL-1β is vital for NK cell production of the anti-pathogen cytokine interferon-gamma, which is critical for the body′s defense against infections. Beyond normal immune function, IL-1β has been implicated in various pathological conditions, including rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis, highlighting IL-1β′s significance in both health and disease. IL-1β monoclonal antibody (2H12) serves as an invaluable tool for researchers studying the complex roles of IL-1β in immune regulation and contributions to inflammatory diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-1 beta/IL1B Antibody (2H12) | sc-130323 | 200 µg/ml | $316.00 |