IL-17RB Antibody (TJ-5): sc-73969

IL-17RB Antibody (TJ-5) is a rat monoclonal IgG2b antibody that detects the IL-17RB protein of mouse origin by western blotting (WB) and immunoprecipitation (IP). Anti-IL-17RB antibody (TJ-5) is available as a non-conjugated format. IL-17RB protein is a crucial member of the cytokine receptor family, functioning primarily as a receptor for the proinflammatory cytokines IL-17B and IL-17E. This interaction plays a vital role in mediating inflammatory responses and regulating immune system activities, which are essential for maintaining homeostasis and responding to pathogens. IL-17RB expression is notably high in various tissues, including the liver, colon, brain, kidney, and testis, indicating importance in diverse physiological processes. IL-17RB has been implicated in the differentiation and growth of hematopoietic cells, highlighting potential role in immune cell development. IL-17RB is also detected in fibroblast-like synoviocytes from patients with rheumatoid arthritis, suggesting involvement in autoimmune conditions. With ability to facilitate critical signaling pathways, IL-17RB is a key player in the immune response, making anti-IL-17RB antibody (TJ-5) an invaluable tool for researchers studying cytokine signaling and related pathologies.

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IL-17RB Antibody (TJ-5) References:

1. Evi27 encodes a novel membrane protein with homology to the IL17 receptor.  |  Tian, E., et al. 2000. Oncogene. 19: 2098-109. PMID: 10815801
2. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways.  |  Hwang, SY., et al. 2004. Arthritis Res Ther. 6: R120-8. PMID: 15059275
3. Cloning of a new cytokine that induces IFN-gamma production by T cells.  |  Okamura, H., et al. 1995. Nature. 378: 88-91. PMID: 7477296
4. Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.  |  Arend, WP., et al. 1994. J Immunol. 153: 4766-74. PMID: 7963543
5. Cytokine function: a study in biologic diversity.  |  Cohen, MC. and Cohen, S. 1996. Am J Clin Pathol. 105: 589-98. PMID: 8623768
6. Janus kinases in cytokine signalling.  |  Ihle, JN. 1996. Philos Trans R Soc Lond B Biol Sci. 351: 159-66. PMID: 8650262

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-17RB Antibody (TJ-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-17RB Antibody (TJ-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-17RB Antibody (TJ-5) Specifications

Alternate Product Name: IL-17RB

Product Clone Name: TJ-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: IL-17RB

Epitope Species: mouse

Product Reactivity/Detection: IL-17RB

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IL-17RB Antibody (TJ-5): N/A