IL-12A p35 Antibody (C7.4): sc-517383

IL-12A p35 Antibody (C7.4) is a mouse monoclonal IgG antibody that detects interleukin-12A p35 in human samples through enzyme-linked immunosorbent assay (ELISA). Interleukin-12A p35 is a crucial component of the heterodimeric cytokine interleukin-12, which plays a significant role in the immune response by promoting the differentiation of T helper cells and enhancing the production of interferon-γ (IFN-γ) from T cells and natural killer (NK) cells. This cytokine is secreted by various antigen-presenting cells, including phagocytes and B cells, and is vital for mediating antiviral immunity, particularly during infections caused by viruses such as Epstein-Barr virus (EBV), cytomegalovirus (CMV), lymphocytic choriomeningitis virus (LCMV), and herpes simplex virus (HSV). The interleukin-12A p35 subunit is believed to be the biologically active component responsible for signal transduction through the IL-12 receptor, making interleukin-12A p35 essential for initiating and regulating immune responses. Understanding the function of interleukin-12A p35 is important for developing therapeutic strategies aimed at enhancing immune responses in various diseases, including cancer and chronic infections. Anti-IL-12A p35 antibody (C7.4) is an invaluable tool for researchers studying the intricate mechanisms of immune regulation and the potential therapeutic applications of interleukin-12.

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IL-12A p35 Antibody (C7.4) References:

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2. Identification of a new isoform of human IL-12 p35 mRNA.  |  Johansson, U., et al. 2002. Eur J Immunogenet. 29: 439-44. PMID: 12358856
3. Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells.  |  van Seventer, JM., et al. 2002. J Neuroimmunol. 133: 60-71. PMID: 12446009
4. Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein.  |  Liu, J., et al. 2004. J Biol Chem. 279: 55609-17. PMID: 15489234
5. IRF-1 and NF-kappaB p50/cRel bind to distinct regions of the proximal murine IL-12 p35 promoter during costimulation with IFN-gamma and LPS.  |  Kollet, JI. and Petro, TM. 2006. Mol Immunol. 43: 623-33. PMID: 15871905
6. Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.  |  Spensieri, F., et al. 2006. Infect Immun. 74: 2831-8. PMID: 16622221
7. Reduced expression of IL-12 p35 by SJL/J macrophages responding to Theiler's virus infection is associated with constitutive activation of IRF-3.  |  Dahlberg, A., et al. 2006. Virology. 353: 422-32. PMID: 16824573
8. Antitumor effects of a tumor cell vaccine expressing a membrane-bound form of the IL-12 p35 subunit.  |  Lim, HY., et al. 2010. Cancer Biol Ther. 10: 336-43. PMID: 20534980
9. Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.  |  Snijders, A., et al. 1996. J Immunol. 156: 1207-12. PMID: 8557999
10. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.  |  Devergne, O., et al. 1997. Proc Natl Acad Sci U S A. 94: 12041-6. PMID: 9342359