IL-12A p35 Antibody (C18.2) is a rat monoclonal IgG2a antibody that detects interleukin-12A p35 in mouse and rat samples through flow cytometry (FCM). IL-12A p35 is a crucial subunit of the heterodimeric cytokine interleukin-12, which plays a significant role in the immune response by promoting the differentiation of T helper cells and enhancing the production of interferon-γ (IFN-γ) from T cells and natural killer (NK) cells. Various antigen-presenting cells, including phagocytes and B cells, secrete this cytokine, which is vital for mediating antiviral immunity. IL-12A p35′s importance extends beyond its role as a signaling molecule to its ability to influence immune system responses to infections, such as those caused by Epstein-Barr virus (EBV) and cytomegalovirus (CMV). IL-12A p35 subunit functions as the biologically active component responsible for signal transduction through the IL-12 receptor, making anti-IL-12A p35 antibody (C18.2) an invaluable tool for researchers studying immune mechanisms and cytokine signaling pathways.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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IL-12A p35 Antibody (C18.2) References:
- A study on the expression of interleukin (IL)-10 and IL-12 P35, P40 mRNA in the psoriatic lesions. | Cheng, J., et al. 2001. J Tongji Med Univ. 21: 86-8. PMID: 11523260
- Production of biologically active equine interleukin 12 through expression of p35, p40 and single chain IL-12 in mammalian and baculovirus expression systems. | McMonagle, EL., et al. 2001. Equine Vet J. 33: 693-8. PMID: 11770992
- Modulation of IL-12 p35 and p40 promoter activity by smokeless tobacco extract is associated with an effect upon activation of NF-kappaB but not IRF transcription factors. | Petro, TM. 2003. Int Immunopharmacol. 3: 735-45. PMID: 12757742
- Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. | Liu, J., et al. 2003. J Exp Med. 198: 1265-76. PMID: 14568984
- A defect in nucleosome remodeling prevents IL-12(p35) gene transcription in neonatal dendritic cells. | Goriely, S., et al. 2004. J Exp Med. 199: 1011-6. PMID: 15051764
- IL-12 p35 silenced dendritic cells modulate immune responses by blocking IL-12 signaling through JAK-STAT pathway in T lymphocytes. | Xu, H., et al. 2007. Biochem Biophys Res Commun. 353: 812-6. PMID: 17194445
- High IL-12 p35 and IL-23 p19 mRNA expression is associated with superior outcome in ovarian cancer. | Wolf, AM., et al. 2010. Gynecol Oncol. 118: 244-50. PMID: 20603238
- Contribution of interleukin-12 p35 (IL-12p35) and IL-12p40 to protective immunity and pathology in mice infected with Chlamydia muridarum. | Chen, L., et al. 2013. Infect Immun. 81: 2962-71. PMID: 23753624
- Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-γ- and TNF-α-co-producing T cell-mediated antitumor immunity. | Choi, IK., et al. 2013. PLoS One. 8: e67512. PMID: 23844018
- Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege. | Terayama, H., et al. 2014. PLoS One. 9: e96120. PMID: 24760014