IL-12 p70 Antibody (QS-12p70): sc-57257

IL-12 p70 Antibody (QS-12p70) is a mouse monoclonal IgG1 antibody that detects interleukin-12 p70 in human samples through enzyme-linked immunosorbent assay (ELISA). Interleukin-12 p70 (IL-12 p70) plays a crucial role in the immune response by promoting the differentiation of naive CD4(+) T cells into type 1 helper T cells, which are essential for the production of interferon-γ (IFN-γ). IL-12 p70 enhances the immune system′s ability to combat infections and tumors by activating natural killer (NK) cells and stimulating the production of tumor necrosis factor α (TNF-α). IL-12 p70 inhibits the suppressive effects of interleukin-4 on IFN-γ production, thereby ensuring a robust immune response. IL-12 p70 regulation is complex, as production occurs in response to various pathogens and is controlled by both p35 and p40 subunits in a cell type-specific manner. IL-12 p70′s ability to enhance immune responses and involvement in anti-angiogenic activity, through the induction of proteins like inducible protein-10 (IP-10), underscores its importance in immunological research and therapeutic applications.