IL-12 p70 Antibody (EQ-7): sc-74151

IL-12 p70 Antibody (EQ-7) is a rat monoclonal IgG1 antibody that detects IL-12 p70 in mouse samples through applications such as western blotting (WB) (non-reducing) and enzyme-linked immunosorbent assay (ELISA). IL-12 p70 is a crucial cytokine that plays a significant role in the immune response by promoting the differentiation of naive CD4(+) T cells into type 1 helper T cells, which are essential for the production of interferon-γ (IFN-γ). This process is vital for enhancing the immune system′s ability to combat infections and tumors, as IFN-γ activates macrophages and natural killer cells, leading to increased production of tumor necrosis factor α (TNF-α). Furthermore, IL-12 p70 is composed of two subunits, p35 and p40, which are regulated in a cell type-specific manner, allowing for precise control of immune responses. The ability of IL-12 p70 to inhibit IL-4 mediated suppression of IFN-γ production underscores its importance in maintaining a robust immune response. Additionally, IL-12 p70 exhibits anti-angiogenic properties, as IL-12 p70 stimulates the production of inducible protein-10 (IP-10) in response to IFN-γ, further highlighting its multifaceted role in immune regulation and potential therapeutic applications.