IL-10R Antibody (3F9): sc-53654
- IL-10R Antibody (3F9) is a rat monoclonal IgG2a, cited in 2 publications, provided at 100 µg/ml
- raised against full length soluble IL-10R of human origin
- recommended for detection of IL-10R of human origin by WB, IP, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-10R Antibody (3F9). This work is in progress.
IL-10R Antibody (3F9) is a rat monoclonal IgG2a antibody that detects IL-10R in human samples through western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IL-10R, a member of the class II cytokine receptor family, plays a crucial role in immune regulation by mediating the effects of the anti-inflammatory cytokine IL-10. IL-10R is primarily located on the surface of immune cells, including B cells and T helper cells, which allows for the modulation of immune responses, particularly in inflammation and autoimmunity. Upon binding of IL-10, IL-10R undergoes a conformational change that activates associated Janus kinases (JAK1 and Tyk2), leading to phosphorylation of specific tyrosine residues in the receptor′s cytoplasmic domain. This phosphorylation is essential for recruiting signaling molecules and activating the IL-10 signaling pathway, which promotes anti-inflammatory responses. IL-10R forms heterodimers with other receptors, such as IL-22R and IL-28R, further expanding its role in immune signaling. Anti-IL-10R antibody (3F9) serves as an invaluable tool for researchers studying immune regulation mechanisms and the therapeutic potential of targeting IL-10 signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-10R Antibody (3F9) | sc-53654 | 100 µg/ml | $322.00 |