Molecular structure of IKK 16, CAS Number: 1186195-62-9
IKK 16 (CAS 1186195-62-9)
See product citations (2)
Alternate Names:
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride;IKK-16 HCl; IKK-16 HCl
Application:
IKK 16 is a selective inhibitor of IκB kinase and IκB degredation
CAS Number:
1186195-62-9
Purity:
>98%
Molecular Weight:
520.09
Molecular Formula:
C28H29N5OS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IKK 16 is a selective inhibitor of IκB kinase (IKK). IKK 16 is a small molecule that targets the catalytic subunit of IKK, preventing the phosphorylation and subsequent degradation of IκBα. This inhibition leads to the sequestration of NF-κB in the cytoplasm, preventing its translocation to the nucleus and subsequent gene transcription. IKK 16 blocks the NF-κB signaling pathway in various cell types, making it for studying the role of NF-κB in inflammation, immunity, and cancer.
IKK 16 (CAS 1186195-62-9) References
- Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK. | Waelchli, R., et al. 2006. Bioorg Med Chem Lett. 16: 108-12. PMID: 16236504
- Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. | Coldewey, SM., et al. 2013. Dis Model Mech. 6: 1031-42. PMID: 23649820
- Improvement of ventilation-induced lung injury in a rodent model by inhibition of inhibitory κB kinase. | Shu, YS., et al. 2014. J Trauma Acute Care Surg. 76: 1417-24. PMID: 24854310
- Increased Interleukin-23 in Hashimoto's Thyroiditis Disease Induces Autophagy Suppression and Reactive Oxygen Species Accumulation. | Zheng, T., et al. 2018. Front Immunol. 9: 96. PMID: 29434604
- miR-124-3p is a chronic regulator of gene expression after brain injury. | Vuokila, N., et al. 2018. Cell Mol Life Sci. 75: 4557-4581. PMID: 30155647
- Topical Application of a Dual ABC Transporter Substrate and NF-κB Inhibitor Blocks Multiple Sources of Cutaneous Inflammation in Mouse Skin. | Li, L., et al. 2019. J Invest Dermatol. 139: 1506-1515.e7. PMID: 30684549
- Small molecule inhibitors of IκB kinase β: A chip-based screening and molecular docking simulation. | Cho, YW., et al. 2020. Bioorg Med Chem. 28: 115440. PMID: 32205046
- PTPIP51 crosslinks the NFκB signaling and the MAPK pathway in SKBR3 cells. | Dietel, E., et al. 2020. Future Sci OA. 6: FSO463. PMID: 32518680
- Suppression of HIV-1 Viral Replication by Inhibiting Drug Efflux Transporters in Activated Macrophages. | Mu, Y. and Cory, TJ. 2021. Curr HIV Res. 19: 128-137. PMID: 33032513
- Epithelial PBLD attenuates intestinal inflammatory response and improves intestinal barrier function by inhibiting NF-κB signaling. | Chen, S., et al. 2021. Cell Death Dis. 12: 563. PMID: 34059646
- Small Molecule Inhibitors Targeting Nuclear Factor κB Activation Markedly Reduce Expression of Interleukin-2, but Not Interferon-γ, Induced by Phorbol Esters and Calcium Ionophores. | Tanaka, Y., et al. 2021. Int J Mol Sci. 22: PMID: 34884902
- ST08 Altered NF-κB Pathway in Breast Cancer Cells In Vitro as Revealed by miRNA-mRNA Analysis and Enhanced the Effect of Cisplatin on Tumour Reduction in EAC Mouse Model. | Nirgude, S., et al. 2022. Front Oncol. 12: 835027. PMID: 35615145
- KL-FGF23-VD Axis in Improving Late-Onset Alzheimer's Disease by Modulating IKK/NF-κB Signal Pathway. | Cai, Y., et al. 2022. Evid Based Complement Alternat Med. 2022: 3100621. PMID: 36118087
Inhibitor of:
Arf2, C16orf62, CARD14, CD16-2, CLEC-2L, FBXW18, FCAMR, FLJ36848, GIMAP2, HTLV-1 Tax, IκB-ε, ICAM-2, ICAP-1, IIGP, IKK alpha, IKK beta, IL-17D, KSHV ORF 45, LOC100041314, LOC100041425, LOC646037, LOC729464, LRRC63, Ly6g, MuRF3, NLF2, PHF11, Rab11-FIP1, Rabaptin-5β, RCBTB2, RUNDC1, SIKE, SPATA13, Spi9, stefin A3, TIP-1, TRAF4, TRB-2, TREM-5, TRIM30, TRIM30A, Tropomyosin β, YPEL3, ZBED5, ZFP772, ZNF37A, ZNF462, ZNF470, and ZNF545.Activator of:
RelB.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKK 16, 10 mg | sc-204009 | 10 mg | $223.00 | |||
IKK 16, 50 mg | sc-204009A | 50 mg | $942.00 |