IκB-β Antibody (H-3): sc-515699

IκB-β Antibody (H-3) is a mouse monoclonal IgG3 antibody that detects IκB-β in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IκB-β plays a crucial role in the regulation of the NF-kB signaling pathway, which is essential for controlling immune responses, inflammation, and cell survival. By sequestering NF-kB dimers in the cytoplasm, IκB-β prevents their translocation to the nucleus, thereby inhibiting the transcription of target genes involved in these processes. The importance of IκB-β extends to its involvement in various cellular responses, including apoptosis and proliferation, making IκB-β a significant player in both normal physiology and disease states such as cancer and autoimmune disorders. Additionally, IκB-β undergoes post-translational modifications, including phosphorylation, which can influence stability and interaction with NF-kB complexes. This dynamic regulation underscores IκB-β′s importance in maintaining cellular homeostasis and responding to extracellular signals, highlighting IκB-β′s potential as a therapeutic target in diseases characterized by dysregulated NF-kB activity. Anti-IκB-β antibody (H-3) serves as an invaluable tool for researchers investigating the complexities of NF-kB signaling and its implications in health and disease.

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IκB-β Antibody (H-3) References:

1. Nuclear IkappaBbeta maintains persistent NF-kappaB activation in HIV-1-infected myeloid cells.  |  DeLuca, C., et al. 1999. J Biol Chem. 274: 13010-6. PMID: 10224051
2. beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta.  |  Wu, C. and Ghosh, S. 1999. J Biol Chem. 274: 29591-4. PMID: 10514424
3. IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation.  |  Fan, C., et al. 2004. J Clin Invest. 113: 746-55. PMID: 14991073
4. In vivo binding of NF-kappaB to the IkappaBbeta promoter is insufficient for transcriptional activation.  |  Griffin, BD. and Moynagh, PN. 2006. Biochem J. 400: 115-25. PMID: 16792530
5. MEOX2 regulates nuclear factor-kappaB activity in vascular endothelial cells through interactions with p65 and IkappaBbeta.  |  Chen, Y., et al. 2010. Cardiovasc Res. 87: 723-31. PMID: 20421348
6. Mannose-mediated inhibitory effects of PA-MSHA on invasion and metastasis of hepatocellular carcinoma via EGFR/Akt/IκBβ/NF-κB pathway.  |  Li, T., et al. 2015. Liver Int. 35: 1416-29. PMID: 25066210
7. Listeria monocytogenes infection of P388D1 macrophages results in a biphasic NF-kappaB (RelA/p50) activation induced by lipoteichoic acid and bacterial phospholipases and mediated by IkappaBalpha and IkappaBbeta degradation.  |  Hauf, N., et al. 1997. Proc Natl Acad Sci U S A. 94: 9394-9. PMID: 9256493
8. Rapid Up-regulation of IkappaBbeta and abrogation of NF-kappaB activity in peritoneal macrophages stimulated with lipopolysaccharide.  |  Velasco, M., et al. 1997. J Biol Chem. 272: 23025-30. PMID: 9287299
9. Persistent activation of RelA by respiratory syncytial virus involves protein kinase C, underphosphorylated IkappaBbeta, and sequestration of protein phosphatase 2A by the viral phosphoprotein.  |  Bitko, V. and Barik, S. 1998. J Virol. 72: 5610-8. PMID: 9621019
10. Assignment of the IkappaB-beta gene NFKBIB to human chromosome band 19q13.1 by in situ hybridization.  |  Okamoto, T., et al. 1998. Cytogenet Cell Genet. 82: 105-6. PMID: 9763672

The preferred IκB-β antibody is IκB-β Antibody (D-3): sc-74451.