Molecular structure of IIK7
IIK7
See product citations (3)
Alternate Names:
N-[2-(2-methoxy-6H-isoindolo[2,1-a]indol-11-yl)ethyl]butanamide
Application:
IIK7 is a melatonin receptor agonist.
Molecular Weight:
348.44
Molecular Formula:
C22H24N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IIK7 is a chemical compound that functions as a potent inhibitor of a specific enzyme involved in cellular signaling pathways. It exerts its mechanism of action by binding to the active site of the enzyme, thereby preventing its normal function and disrupting downstream signaling. This disruption ultimately leads to alterations in cellular processes, making IIK7 a valuable for studying the role of the targeted enzyme in various biological pathways. Targeting this enzyme, IIK7 can provide insights into the molecular mechanisms underlying certain cellular functions and contribute to the development of new strategies aimed at modulating these pathways. Its precise mechanism of action at the molecular level makes IIK7 a useful compound for investigating the signaling networks within cells.
IIK7 References
- Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles. | Faust, R., et al. 2000. J Med Chem. 43: 1050-61. PMID: 10737738
- Sympathetic nervous system modulates the ocular hypotensive action of MT2-melatonin receptors in normotensive rabbits. | Alarma-Estrany, P., et al. 2008. J Pineal Res. 45: 468-75. PMID: 18673419
- Sleep-promoting action of IIK7, a selective MT2 melatonin receptor agonist in the rat. | Fisher, SP. and Sugden, D. 2009. Neurosci Lett. 457: 93-6. PMID: 19429170
- Melatonin receptor agonists: new options for insomnia and depression treatment. | Spadoni, G., et al. 2011. CNS Neurosci Ther. 17: 733-41. PMID: 21554566
- Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells. | Dortch-Carnes, J. and Tosini, G. 2013. Exp Eye Res. 107: 1-10. PMID: 23201027
- Effect of melatonin and analogues on corneal wound healing: involvement of Mt2 melatonin receptor. | Crooke, A., et al. 2015. Curr Eye Res. 40: 56-65. PMID: 24892818
- Understanding melatonin receptor pharmacology: latest insights from mouse models, and their relevance to human disease. | Tosini, G., et al. 2014. Bioessays. 36: 778-87. PMID: 24903552
- Beneficial effects of melatonin on bovine oocytes maturation: a mechanistic approach. | Tian, X., et al. 2014. J Pineal Res. 57: 239-47. PMID: 25070516
- Melatonin modulates the functions of porcine granulosa cells via its membrane receptor MT2 in vitro. | He, YM., et al. 2016. Anim Reprod Sci. 172: 164-72. PMID: 27477115
- Pretraining hippocampal stimulation of melatonin type 2 receptors can improve memory acquisition in rats. | Beigi, B., et al. 2019. Int J Neurosci. 129: 492-500. PMID: 30431374
- Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep. | Gobbi, G. and Comai, S. 2019. J Pineal Res. 66: e12544. PMID: 30586215
- Effect of Melatonin and Its Analogs on Tear Secretion. | Navarro Gil, FJ., et al. 2019. J Pharmacol Exp Ther. 371: 186-190. PMID: 31371479
- Melatonin MT2 receptor agonist IIK-7 produces antinociception by modulation of ROS and suppression of spinal microglial activation in neuropathic pain rats. | Kuthati, Y., et al. 2019. J Pain Res. 12: 2473-2485. PMID: 31496789
- Melatonin Attenuates Anoxia/Reoxygenation Injury by Inhibiting Excessive Mitophagy Through the MT2/SIRT3/FoxO3a Signaling Pathway in H9c2 Cells. | Wu, J., et al. 2020. Drug Des Devel Ther. 14: 2047-2060. PMID: 32546969
- The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors. | Arjoune, A. and Sirard, MA. 2022. Sci Rep. 12: 17539. PMID: 36266374
Activator of:
MEL-1A-R, and MEL-1B-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IIK7, 1 mg | sc-300823 | 1 mg | $68.00 | |||
IIK7, 5 mg | sc-300823A | 5 mg | $208.00 |