IgG₄ Antibody (5C3): sc-69919

IgG4 Antibody (5C3) is a mouse monoclonal IgG1 antibody that detects the IgG4 protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-IgG4 antibody (5C3) is available as a non-conjugated format, specifically designed to provide reliable detection of IgG4 levels in various biological samples. IgG4 (5C3) antibody plays a crucial role in the immune response, particularly in modulating allergic reactions and autoimmune diseases, as IgG4 is known to inhibit the activity of other immunoglobulin subclasses. This unique function is vital because IgG4 helps to balance the immune response, preventing excessive inflammation and tissue damage. Notably, IgG4 is often associated with chronic conditions, and IgG4 levels can be indicative of certain diseases, including IgG4-related disease, which can lead to significant organ damage if left untreated. Research has shown that a significant number of patients with recurrent respiratory tract infections exhibit low concentrations of IgG4, highlighting IgG4′s importance in maintaining immune homeostasis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

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IgG₄ Antibody (5C3) References:

1. Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA.  |  Tucker, PW., et al. 1979. Science. 206: 1299-303. PMID: 117548
2. Nucleotide sequence of a human immunoglobulin C gamma 4 gene.  |  Ellison, J., et al. 1981. DNA. 1: 11-8. PMID: 6299662
3. Restriction fragment length polymorphisms associated with immunoglobulin C gamma genes reveal linkage disequilibrium and genomic organization.  |  Bech-Hansen, NT., et al. 1983. Proc Natl Acad Sci U S A. 80: 6952-6. PMID: 6316337
4. The role of gene deletion in the immunoglobulin heavy chain switch.  |  Rabbitts, TH., et al. 1980. Nature. 283: 351-6. PMID: 6766206
5. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.  |  Sakano, H., et al. 1980. Nature. 286: 676-83. PMID: 6774258
6. Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes.  |  Kirsch, IR., et al. 1982. Science. 216: 301-3. PMID: 6801764
7. Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.  |  Adetugbo, K. 1978. J Biol Chem. 253: 6068-75. PMID: 98524

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IgG₄ Antibody (5C3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IgG₄ Antibody (5C3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IgG₄ Antibody (5C3) Specifications

Alternate Product Name: IgG4

Product Clone Name: 5C3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: IgG₄

Epitope Species: human

Product Reactivity/Detection: IgG4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IgG₄ Antibody (5C3): N/A