IgG₃ Antibody (5H9-2a): sc-69918

IgG3 Antibody (5H9-2a) is a mouse monoclonal IgG2b antibody that detects the IgG3 protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-IgG3 antibody (5H9-2a) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important immunoglobulin subclass. IgG3 is notable for its unique structure, which includes a longer hinge region compared to other IgG subclasses, allowing for greater flexibility and enhanced binding to antigens. This structural characteristic enables IgG3 to effectively engage with a wide range of pathogens, including viruses and bacteria, facilitating a robust immune response. IgG3′s ability to form immune complexes and activate complement pathways is particularly significant, as IgG3 plays a vital role in opsonization and clearance of pathogens from the body. IgG3′s capacity to cross-link antigens enhances effectiveness in neutralizing toxins, making IgG3 an essential component of the adaptive immune system. With critical functions and unique structural properties, IgG3 Antibody (5H9-2a) serves as an invaluable resource for researchers investigating IgG3′s role in health and disease.

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IgG₃ Antibody (5H9-2a) References:

1. Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum.  |  Wuhrer, M., et al. 2007. Proteomics. 7: 4070-81. PMID: 17994628
2. Inheritance of a large deletion within the human immunoglobulin heavy chain constant region gene complex and immunological implications.  |  Hendriks, RW., et al. 1989. Scand J Immunol. 29: 535-41. PMID: 2567054
3. Human immunoglobulin G and immunoglobulin G subclasses: biochemical, genetic, and clinical aspects.  |  Papadea, C. and Check, IJ. 1989. Crit Rev Clin Lab Sci. 27: 27-58. PMID: 2647414
4. Biological role of different antibody classes.  |  Spiegelberg, HL. 1989. Int Arch Allergy Appl Immunol. 90 Suppl 1: 22-7. PMID: 2693365
5. The role of gene deletion in the immunoglobulin heavy chain switch.  |  Rabbitts, TH., et al. 1980. Nature. 283: 351-6. PMID: 6766206
6. Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.  |  Adetugbo, K. 1978. J Biol Chem. 253: 6068-75. PMID: 98524
7. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.  |  Sakano, H., et al. 1980. Nature. 286: 676-83. PMID: 6774258
8. IgG3 is the major source of cryoglobulins in mice.  |  Abdelmoula, M., et al. 1989. J Immunol. 143: 526-32. PMID: 2738401

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IgG₃ Antibody (5H9-2a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IgG₃ Antibody (5H9-2a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IgG₃ Antibody (5H9-2a) Specifications

Alternate Product Name: IgG3

Product Clone Name: 5H9-2a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: IgG₃

Epitope Species: human

Product Reactivity/Detection: IgG3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IgG₃ Antibody (5H9-2a): N/A