IgG_2b Antibody (SB74g): sc-69817

IgG2b Antibody (SB74g) is a rat monoclonal IgG1 antibody that detects the IgG2b protein of mouse origin by immunofluorescence (IF) and flow cytometry (FCM). Anti-IgG2b antibody (SB74g) is available as a non-conjugated format, providing researchers with a versatile tool for studying immune responses. IgG2b is one of the four subclasses of immunoglobulin G (IgG), which also include IgG1, IgG3, and IgG4. Each subclass plays a unique role in the immune system, with IgG2b being particularly important in the response to certain types of pathogens, such as viruses and bacteria. IgG2b is characterized by its ability to activate complement pathways and mediate opsonization, enhancing the phagocytosis of pathogens. Understanding IgG2b function is crucial, as IgG2b contributes to the overall effectiveness of the immune response, particularly in the context of infections and autoimmune diseases. The structure of IgG2b, which consists of two heavy chains and two light chains forming a Y-shaped molecule, allows for the binding of multiple antigens, thereby increasing efficacy in neutralizing threats to the body. Anti-IgG2b antibody (SB74g) serves as an essential reagent for researchers investigating the complexities of the immune system in mouse models.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IgG_2b Antibody (SB74g) References:

1. Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA.  |  Tucker, PW., et al. 1979. Science. 206: 1299-303. PMID: 117548
2. Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction.  |  Fuchs, S., et al. 2007. Ann N Y Acad Sci. 1110: 550-8. PMID: 17911471
3. Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life.  |  Nair, N., et al. 2007. J Infect Dis. 196: 1339-45. PMID: 17922398
4. Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum.  |  Wuhrer, M., et al. 2007. Proteomics. 7: 4070-81. PMID: 17994628
5. The role of gene deletion in the immunoglobulin heavy chain switch.  |  Rabbitts, TH., et al. 1980. Nature. 283: 351-6. PMID: 6766206
6. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.  |  Sakano, H., et al. 1980. Nature. 286: 676-83. PMID: 6774258
7. Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.  |  Adetugbo, K. 1978. J Biol Chem. 253: 6068-75. PMID: 98524

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IgG_2b Antibody (SB74g) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IgG_2b Antibody (SB74g) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IgG_2b Antibody (SB74g) Specifications

Alternate Product Name: IgG2b

Product Clone Name: SB74g

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: IgG_2b

Epitope Species: mouse

Product Reactivity/Detection: IgG_2b heavy chain

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IgG_2b Antibody (SB74g): N/A