IgG₂ Antibody (52G1): sc-52005

IgG2 Antibody (52G1) is a mouse monoclonal IgG2a antibody that detects the IgG2 protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-IgG2 antibody (52G1) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important immunoglobulin subclass. IgG2 is primarily located in the bloodstream and plays a crucial role in the immune response, particularly in combating infections caused by encapsulated bacteria. IgG2′s ability to effectively opsonize pathogens enhances recognition and clearance by phagocytic cells, making IgG2 vital for maintaining immune defense. Additionally, IgG2 is known for unique structural features, including a lower affinity for Fc receptors compared to other IgG subclasses, which influences functional properties and interactions with immune cells. Understanding IgG2 dynamics and interactions is essential for developing therapeutic strategies and vaccines, as well as for advancing knowledge of immune system functioning.

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IgG₂ Antibody (52G1) References:

1. Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA.  |  Tucker, PW., et al. 1979. Science. 206: 1299-303. PMID: 117548
2. Suppression of experimental autoimmune myasthenia gravis by intravenous immunoglobulin and isolation of a disease-specific IgG fraction.  |  Fuchs, S., et al. 2007. Ann N Y Acad Sci. 1110: 550-8. PMID: 17911471
3. Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life.  |  Nair, N., et al. 2007. J Infect Dis. 196: 1339-45. PMID: 17922398
4. Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum.  |  Wuhrer, M., et al. 2007. Proteomics. 7: 4070-81. PMID: 17994628
5. The role of gene deletion in the immunoglobulin heavy chain switch.  |  Rabbitts, TH., et al. 1980. Nature. 283: 351-6. PMID: 6766206
6. Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes.  |  Sakano, H., et al. 1980. Nature. 286: 676-83. PMID: 6774258
7. Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain.  |  Adetugbo, K. 1978. J Biol Chem. 253: 6068-75. PMID: 98524

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IgG₂ Antibody (52G1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IgG₂ Antibody (52G1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IgG₂ Antibody (52G1) Specifications

Alternate Product Name: IgG2

Product Clone Name: 52G1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: IgG₂

Epitope Species: human

Product Reactivity/Detection: γ-2 epitope inside Fc fragment of IgG2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IgG₂ Antibody (52G1): N/A