IGFBP5 Antibody (D-6): sc-515116

IGFBP5 Antibody (D-6) is a mouse monoclonal IgA kappa light chain antibody that detects IGFBP5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IGFBP5 antibody (D-6) is available as the non-conjugated monoclonal isotype antibody. Insulin-like growth factor-binding proteins (IGFBPs) are a crucial family of proteins that not only transport insulin-like growth factors (IGFs) but also regulate their signaling pathways, thereby influencing various biological processes such as growth, development, and metabolism. Among the seven known IGFBPs, IGFBP5 is particularly significant as IGFBP5 is secreted by myoblasts and plays a vital role in muscle differentiation, which is essential for muscle development and repair. IGFBP5 interaction with IGFs modulates their bioavailability and activity, impacting muscle regeneration and overall metabolic health. Additionally, IGFBP5 expression can be influenced by various physiological conditions, making IGFBP5 a key player in the regulation of growth factor signaling in different tissues. With IGFBP5′s ability to bind IGFs and potentially exert biological effects independent of them, IGFBP5 is an important target for research in muscle biology and metabolic disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IGFBP5 Antibody (D-6) References:

1. Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells.  |  Wang, J., et al. 2015. Oncotarget. 6: 20636-49. PMID: 26010068
2. IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis.  |  Song, C., et al. 2022. Cell Death Dis. 13: 340. PMID: 35418167
3. Insulin-like growth factor binding protein 5 accelerate the senescence of periodontal ligament stem cells.  |  Li, L., et al. 2023. Cell Tissue Bank. 24: 231-239. PMID: 35939161
4. Insulin-like growth factor binding protein 5: Diverse roles in cancer.  |  Waters, JA., et al. 2022. Front Oncol. 12: 1052457. PMID: 36465383
5. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.  |  Lin, W., et al. 2023. Nat Commun. 14: 1578. PMID: 36949068
6. Insulin-like growth factor binding proteins as glucoregulators.  |  Baxter, RC. 1995. Metabolism. 44: 12-7. PMID: 7476305
7. Structure and localization of the IGFBP-1 gene and its expression during liver regeneration.  |  Lee, J., et al. 1994. Hepatology. 19: 656-65. PMID: 7509771
8. Insulin-like growth factors.  |  Schmid, C. 1995. Cell Biol Int. 19: 445-57. PMID: 7640658
9. The IGF system in metabolism regulation.  |  Binoux, M. 1995. Diabete Metab. 21: 330-7. PMID: 8586149
10. Differential expression of IGFBPs by normal and hypertrophic scar fibroblasts.  |  Hathaway, CL., et al. 1996. J Surg Res. 60: 156-62. PMID: 8592408
11. Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics.  |  Kelley, KM., et al. 1996. Int J Biochem Cell Biol. 28: 619-37. PMID: 8673727
12. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.  |  Oh, Y., et al. 1996. J Biol Chem. 271: 30322-5. PMID: 8939990

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGFBP5 Antibody (D-6) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-IGFBP5 Antibody (D-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGFBP5 Antibody (D-6) Specifications

Alternate Product Name: IGFBP5

Product Clone Name: D-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA kappa light chain

Amino Acids: 70-89

Epitope Target: IGFBP5

Epitope Species: human

Product Reactivity/Detection: IGFBP5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for IGFBP5 Antibody (D-6): P: Blocking Peptide