IGFBP4 Antibody (A3): sc-517440

IGFBP4 Antibody (A3) is a mouse monoclonal IgG2b kappa light chain antibody that detects IGFBP4 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-IGFBP4 antibody (A3) is available as a non-conjugated format. Insulin-like growth factor-binding proteins (IGFBPs) are a crucial family of proteins that not only transport insulin-like growth factors (IGFs) but also regulate signaling pathways, thereby influencing cellular growth and development. IGFBP4 plays a significant role in modulating IGF bioavailability, which is essential for maintaining proper cellular functions and growth responses. IGFBP4 is primarily located in the extracellular space, where binding to IGFs affects their distribution and activity. This localization allows IGFBP4 to interact with various tissues and organs, thereby influencing processes such as cell proliferation, differentiation, and apoptosis. IGFBP4 has shown biological activities independent of IGFs, further underscoring importance in cellular regulation. Understanding IGFBP4 dynamics and interactions can provide insights into various physiological and pathological conditions, including growth disorders and cancer.

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IGFBP4 Antibody (A3) References:

1. IGFBP-4: A promising biomarker for lung cancer.  |  Nur, SI., et al. 2021. J Med Biochem. 40: 237-244. PMID: 34177367
2. The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels.  |  Alterki, A., et al. 2021. Dis Markers. 2021: 1219593. PMID: 34646401
3. The STC2-PAPP-A-IGFBP4-IGF1 axis and its associations to mortality and CVD in T2D.  |  Gude, MF., et al. 2023. Endocr Connect. 12: PMID: 36607154
4. Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy.  |  AlMajed, HT., et al. 2023. Int J Mol Sci. 24: PMID: 37762544
5. Insulin-like growth factor binding proteins as glucoregulators.  |  Baxter, RC. 1995. Metabolism. 44: 12-7. PMID: 7476305
6. Structure and localization of the IGFBP-1 gene and its expression during liver regeneration.  |  Lee, J., et al. 1994. Hepatology. 19: 656-65. PMID: 7509771
7. Insulin-like growth factors.  |  Schmid, C. 1995. Cell Biol Int. 19: 445-57. PMID: 7640658
8. The IGF system in metabolism regulation.  |  Binoux, M. 1995. Diabete Metab. 21: 330-7. PMID: 8586149
9. Differential expression of IGFBPs by normal and hypertrophic scar fibroblasts.  |  Hathaway, CL., et al. 1996. J Surg Res. 60: 156-62. PMID: 8592408
10. Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics.  |  Kelley, KM., et al. 1996. Int J Biochem Cell Biol. 28: 619-37. PMID: 8673727
11. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.  |  Oh, Y., et al. 1996. J Biol Chem. 271: 30322-5. PMID: 8939990
12. Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4).  |  Zazzi, H., et al. 1998. Genomics. 49: 401-10. PMID: 9615225

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGFBP4 Antibody (A3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IGFBP4 Antibody (A3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGFBP4 Antibody (A3) Specifications

Alternate Product Name: IGFBP4

Product Clone Name: A3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 22-258

Epitope Target: IGFBP4

Epitope Species: human

Product Reactivity/Detection: IGFBP4

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with 50% glycerol

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IGFBP4 Antibody (A3): N/A