IGF-1 Receptor β/IGF1R Antibody (T8C8): sc-81764
- IGF-1 Receptor β/IGF1R Antibody (T8C8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 1101-1367 of IGF-IR of human origin
- recommended for detection of IGF-IRβ of human origin by WB, IP, IF and IHC(P)
- See IGF-1 Receptor β/IGF1R (F-1): sc-390130 for IGF-1 Receptor β/IGF1R antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP is the preferred secondary detection reagent for IGF-1 Receptor β/IGF1R Antibody (T8C8) for WB and IHC(P) applications. This reagent is now offered in a bundle with IGF-1 Receptor β/IGF1R Antibody (T8C8) (see ordering information below).
IGF-IRβ Antibody (T8C8) is a mouse monoclonal IgG2a kappa light chain antibody raised against a recombinant protein corresponding to amino acids 1101-1367 of human IGF-IR, also known as insulin-like growth factor 1 receptor. IGF-IR (T8C8) antibody is validated for applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP), with species reactivity in humans. IGF-IR is a receptor tyrosine kinase located on the plasma membrane, where IGF-IR serves as a critical mediator of insulin-like growth factor I (IGF-I) signaling. This membrane localization is essential for ligand binding and the initiation of downstream signaling pathways, such as the Ras-ERK and PI3K-AKT cascades, which regulate cell proliferation, differentiation, and survival. Composed of α and β subunits, IGF-IR is encoded by the IGF-IR gene on chromosome 15q26.3, with the β subunit containing the intracellular tyrosine kinase domain responsible for propagating signals. The precise membrane localization of IGF-IR enables direct modulation of cellular responses to growth signals, inhibition of apoptosis, and contribution to tissue development and repair. Dysregulation of IGF-IR is associated with various pathological conditions, including cancer, where IGF-IR plays a role in promoting tumor growth and survival. Anti-IGF-IR antibody (T8C8) is a valuable resource for studying the localization and functional roles of IGF-IR in cellular signaling and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IGF-1 Receptor β/IGF1R Antibody (T8C8) | sc-81764 | 200 µg/ml | $322.00 | |||
IGF-1 Receptor β/IGF1R Antibody (T8C8): m-IgG2a BP-HRP Bundle | sc-546013 | 200 µg Ab; 10 µg BP | $361.00 |