IgA₂ Antibody (14AS): sc-51992

IgA2 Antibody (14AS) is a mouse monoclonal IgG1 antibody that detects IgA2 protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-IgA2 antibody (14AS) is available as the non-conjugated monoclonal isotype antibody, specifically designed to provide reliable detection of IgA2 protein, which plays a crucial role in mucosal immunity. IgA2 protein is predominantly found in mucosal secretions, such as colostrum, maternal milk, tears, and saliva, where IgA2 serves as a first line of defense against pathogens. IgA2 in these secretions is vital for protecting mucosal surfaces from infections, as IgA2 can neutralize viruses and bacteria, thereby preventing their entry into the body. IgA2 is produced by B cells located in the mucosae, and IgA2 structure includes both heavy and light chains linked by noncovalent bonds, with carbohydrate attachment sites primarily located in the constant regions. These structural features enhance stability and facilitate interaction with antigens, making IgA2 an essential component of the immune response. Research has shown that mesangial deposits of IgA2 may activate the lectin pathway in patients with IgA glomerulonephritis, highlighting IgA2′s significance in both health and disease.

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IgA₂ Antibody (14AS) References:

1. Cleavage of a recombinant human immunoglobulin A2 (IgA2)-IgA1 hybrid antibody by certain bacterial IgA1 proteases.  |  Senior, BW., et al. 2000. Infect Immun. 68: 463-9. PMID: 10639405
2. The N-glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig)A1 and IgA2 isotypes.  |  Rifai, A., et al. 2000. J Exp Med. 191: 2171-82. PMID: 10859341
3. Increases of IgA milk concentrations correlate with IgA2 increment.  |  Trégoat, V., et al. 2001. J Clin Lab Anal. 15: 55-8. PMID: 11291105
4. [A case of IgA2-lambda type M-protein that IgA concentration differs from the values of M-protein by serum protein electrophoresis].  |  Fukushima, M., et al. 2001. Rinsho Byori. 49: 690-4. PMID: 11519133
5. Hybrid IgA2/IgG1 antibodies with tailor-made effector functions.  |  Chintalacharuvu, KR., et al. 2001. Clin Immunol. 101: 21-31. PMID: 11580223
6. Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis.  |  Hisano, S., et al. 2001. Am J Kidney Dis. 38: 1082-8. PMID: 11684563
7. Cysteine residues required for the attachment of the light chain in human IgA2.  |  Chintalacharuvu, KR., et al. 2002. J Immunol. 169: 5072-7. PMID: 12391223
8. [A case of immunotactoid glomerulopathy with IgA2, kappa deposition ameliorated by steroid therapy].  |  Moriyama, T., et al. 2003. Nihon Jinzo Gakkai Shi. 45: 449-56. PMID: 14509221
9. Solution structure determination of monomeric human IgA2 by X-ray and neutron scattering, analytical ultracentrifugation and constrained modelling: a comparison with monomeric human IgA1.  |  Furtado, PB., et al. 2004. J Mol Biol. 338: 921-41. PMID: 15111057

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IgA₂ Antibody (14AS) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IgA₂ Antibody (14AS) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IgA₂ Antibody (14AS) Specifications

Alternate Product Name: IgA2

Product Clone Name: 14AS

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: IgA₂

Epitope Species: human

Product Reactivity/Detection: Fc-region of IgA₂

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IgA₂ Antibody (14AS): N/A