Ig κ light chain Antibody (2G5-14): sc-69921

Ig κ light chain Antibody (2G5-14) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Ig κ light chain protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Ig κ light chain antibody (2G5-14) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical component of the immune system. Ig κ light chain plays a vital role in forming immunoglobulins, which are essential for adaptive immune response. These immunoglobulins consist of two identical heavy chains and two identical light chains, forming a Y-shaped structure that enables antigen recognition and binding. Kappa light chain presence contributes to antibody diversity produced by B cells, allowing for effective response to various pathogens. Genes encoding κ light chain are located on chromosome 2, and their rearrangement during B cell development generates diverse antibody repertoire. Understanding Ig κ light chain function and significance advances immunological research and therapeutic strategies targeting immune responses.

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Ig κ light chain Antibody (2G5-14) References:

1. The mysterious immunoglobulin light chain.  |  Pilström, L. 2002. Dev Comp Immunol. 26: 207-15. PMID: 11696386
2. Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells.  |  Li, M., et al. 2004. Int J Biochem Cell Biol. 36: 2250-7. PMID: 15313470
3. Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen.  |  Horejsí, V., et al. 1986. Folia Biol (Praha). 32: 12-25. PMID: 2422063
4. Evolution of human immunoglobulin kappa J region genes.  |  Hieter, PA., et al. 1982. J Biol Chem. 257: 1516-22. PMID: 6276389
5. Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes.  |  Durdik, J., et al. Nature. 307: 749-52. PMID: 6422305
6. The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies.  |  Mason, DW., et al. 1981. Immunology. 44: 75-87. PMID: 6456222
7. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.  |  Hieter, PA., et al. 1980. Cell. 22: 197-207. PMID: 6775818
8. Committed T lymphocyte stem cells of rats. Characterization by surface W3/13 antigen and radiosensitivity.  |  Dyer, MJ. and Hunt, SV. 1981. J Exp Med. 154: 1164-77. PMID: 6974759

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ig κ light chain Antibody (2G5-14) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Ig κ light chain Antibody (2G5-14) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ig κ light chain Antibody (2G5-14) Specifications

Alternate Product Name: Ig κ light chain

Product Clone Name: 2G5-14

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Ig κ light chain

Epitope Species: human

Product Reactivity/Detection: Ig κ light chain

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Ig κ light chain Antibody (2G5-14): N/A