IFRD2 Antibody (DD-Z): sc-101071

IFRD2 Antibody (DD-Z) is a mouse monoclonal IgG1 kappa light chain antibody that detects IFRD2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IFRD2 antibody (DD-Z) is available as a non-conjugated monoclonal isotype antibody. IFRD2, also known as Interferon-related developmental regulator 2 or SKMC15, is a 442 amino acid soluble nuclear protein that plays a crucial role in cellular processes. IFRD2 is ubiquitously expressed and features a β-catenin-like repeat, suggesting involvement in the adenomatous polyposis coli (APC) signaling pathway, which is vital for regulating cell growth and differentiation. IFRD2 shares 75% homology with IFRD1 and may influence the expression of surface adhesion molecules essential for the differentiation and fusion of myogenic satellite cells, which are critical for muscle regeneration. While the gene encoding IFRD2 is subject to overlapping homozygous deletions in various lung cancer cell lines, IFRD2 does not exhibit loss-of-function mutations in cancer cells, indicating a potential role in tumor progression and highlighting importance in cancer biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IFRD2 Antibody (DD-Z) References:

1. A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.  |  Gu, W., et al. 1999. Mol Cell. 3: 97-108. PMID: 10024883
2. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.  |  Lerman, MI. and Minna, JD. 2000. Cancer Res. 60: 6116-33. PMID: 11085536
3. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.  |  Shuttleworth, TL., et al. 2002. J Biol Chem. 277: 23008-18. PMID: 11929860
4. Muscle regeneration and myogenic differentiation defects in mice lacking TIS7.  |  Vadivelu, SK., et al. 2004. Mol Cell Biol. 24: 3514-25. PMID: 15060170
5. Identification of New Potential Therapies for Colitis Amelioration Using an Appendicitis-Appendectomy Model.  |  Cheluvappa, R. 2019. Inflamm Bowel Dis. 25: 436-444. PMID: 30329049
6. Structures of translationally inactive mammalian ribosomes.  |  Brown, A., et al. 2018. Elife. 7: PMID: 30355441
7. Data on molecular characterisation and expression analysis of the interferon-related developmental regulator 2 (IFRD2) gene from red sea bream, Pagrus major.  |  Kim, KH., et al. 2019. Data Brief. 25: 104142. PMID: 31516920
8. The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus.  |  Alashmali, SM., et al. 2019. J Neuroinflammation. 16: 237. PMID: 31775778
9. [Interferon-related gene array in predicting the efficacy of interferon therapy in chronic hepatitis B].  |  Wang, J., et al. 2023. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 40: 79-86. PMID: 36854551
10. The human general co-factors.  |  Kaiser, K. and Meisterernst, M. 1996. Trends Biochem Sci. 21: 342-5. PMID: 8870498
11. The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chromosome 3p21.  |  Latif, F., et al. 1997. Hum Genet. 99: 334-41. PMID: 9050919
12. Cloning of the human interferon-related developmental regulator (IFRD1) gene coding for the PC4 protein, a member of a novel family of developmentally regulated genes.  |  Buanne, P., et al. 1998. Genomics. 51: 233-42. PMID: 9722946