Date published: 2026-4-2

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Ifosfamide (CAS 3778-73-2)

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Alternate Names:
Ifex; N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide
Application:
Ifosfamide is a cytostatic agent structurally related to cyclophosphamide
CAS Number:
3778-73-2
Purity:
≥99%
Molecular Weight:
261.09
Molecular Formula:
C7H15Cl2N2O2P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ifosfamide is a compound that finds its application in various research applications. In the field of chemistry, it is studied for its reactivity and the mechanisms by which it forms DNA adducts, which is fundamental in understanding the alkylation of nucleophilic sites in biomolecules. Researchers in molecular biology may use ifosfamide to investigate DNA repair mechanisms by observing how cells respond to alkylation damage. In addition, ifosfamide′s metabolic activation, involving cytochrome P450 enzymes, is of interest in toxicology studies, as it provides insights into the metabolism of nitrogen mustard compounds and the detoxification pathways in organisms. Environmental scientists may also study the degradation products of ifosfamide to assess its persistence and transformation in the environment. Moreover, ifosfamide can be used as a reference compound in the development of analytical methods for the detection and quantification of similar substances in various matrices.


Ifosfamide (CAS 3778-73-2) References

  1. Cyclophosphamide versus ifosfamide: to use ifosfamide or not to use, that is the three-dimensional question.  |  Williams, ML. and Wainer, IW. 1999. Curr Pharm Des. 5: 665-72. PMID: 10469897
  2. Studies on the clinical pharmacology and toxicology of isophosphamide (NSC-109724).  |  Creaven, PJ., et al. 1976. Cancer Treat Rep. 60: 445-9. PMID: 1277220
  3. Use of ifosfamide in the management of breast cancer.  |  Gad-el-Mawla, N. 1992. Ann Oncol. 3 Suppl 3: 21-3. PMID: 1390313
  4. Pharmacology of ifosfamide.  |  Furlanut, M. and Franceschi, L. 2003. Oncology. 65 Suppl 2: 2-6. PMID: 14586139
  5. Ifosfamide. Metabolic studies, new therapeutic approaches and new analogs.  |  Misiura, K. 2006. Mini Rev Med Chem. 6: 395-400. PMID: 16613576
  6. Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer.  |  Dechant, KL., et al. 1991. Drugs. 42: 428-67. PMID: 1720382
  7. Ifosfamide and mesna.  |  Schoenike, SE. and Dana, WJ. 1990. Clin Pharm. 9: 179-91. PMID: 2107997
  8. Ifosfamide--pharmacologic overview.  |  Sarosy, G. 1989. Semin Oncol. 16: 2-8. PMID: 2649983
  9. The role of ifosfamide in testicular cancer.  |  Schmoll, HJ. 1989. Semin Oncol. 16: 82-95. PMID: 2649987
  10. Immunotherapy for osteosarcoma.  |  Yahiro, K. and Matsumoto, Y. 2021. Hum Vaccin Immunother. 17: 1294-1295. PMID: 33356848
  11. Ifosfamide metabolism and pharmacokinetics (review).  |  Kaijser, GP., et al. 1994. Anticancer Res. 14: 517-31. PMID: 8017856
  12. Ifosfamide and mesna in epithelial ovarian carcinoma.  |  Sutton, G. 1993. Gynecol Oncol. 51: 104-8. PMID: 8244163
  13. Ifosfamide, mesna, and nephrotoxicity in children.  |  Skinner, R., et al. 1993. J Clin Oncol. 11: 173-90. PMID: 8418231
  14. Ifosfamide-induced nephrotoxicity in children: critical review of predictive risk factors.  |  Loebstein, R. and Koren, G. 1998. Pediatrics. 101: E8. PMID: 9606250

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ifosfamide, 50 mg

sc-218590
50 mg
$115.00