IFN-γRα Antibody (F-6): sc-74450

IFN-γRα Antibody (F-6) is a mouse monoclonal IgG2a antibody that detects IFN-γRα in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IFN-γRα plays a crucial role in the immune response by serving as a receptor for interferon-gamma, a key cytokine involved in antiviral and immunomodulatory activities. IFN-γRα is primarily located on the surface of immune cells, where IFN-γRα facilitates the binding of interferon-gamma, leading to the activation of intracellular signaling pathways that promote the expression of genes involved in immune responses. This localization is vital because IFN-γRα ensures that immune cells can rapidly respond to infections and other immune challenges, thereby enhancing the body′s ability to fight off pathogens. IFN-γRα functioning depends on interaction with the IFN-γRβ chain, which is essential for receptor signaling capabilities. The proper assembly and function of this receptor complex are critical for the activation of downstream signaling molecules, such as Janus kinases and Stat proteins, which ultimately lead to the transcription of genes that mediate immune responses. Anti-IFN-γRα antibody (F-6) is an invaluable tool for researchers studying the mechanisms of immune regulation and the role of interferon-gamma in various biological processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IFN-γRα Antibody (F-6) References:

1. Polymorphism in the interferon-gamma receptor-1 gene and susceptibility to pulmonary tuberculosis in The Gambia.  |  Newport, MJ., et al. 2003. Scand J Immunol. 58: 383-5. PMID: 14507301
2. Interferon-gamma and interferon-gamma receptor 1 and 2 gene polymorphisms and restenosis following coronary stenting.  |  Tiroch, K., et al. 2005. Atherosclerosis. 182: 145-51. PMID: 16115485
3. Polymorphisms of interferon-gamma and interferon-gamma receptor 1 genes and non-tuberculous mycobacterial lung diseases.  |  Hwang, JH., et al. 2007. Tuberculosis (Edinb). 87: 166-71. PMID: 17023216
4. Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-γ receptor subunit 1 (IFNGR1).  |  Lee, SH., et al. 2013. J Immunol. 191: 4223-34. PMID: 24048899
5. [Interferon-gamma receptor 1 deficiency in a 19-month-old child: case report and literature review].  |  Wang, Q., et al. 2014. Zhonghua Er Ke Za Zhi. 52: 387-91. PMID: 24969940
6. Diagnostic and therapeutic challenges in a child with complete interferon-γ receptor 1 deficiency.  |  Olbrich, P., et al. 2015. Pediatr Blood Cancer. 62: 2036-9. PMID: 26173802
7. Whole-exome sequencing reveals a rare interferon gamma receptor 1 mutation associated with myasthenia gravis.  |  Qi, G., et al. 2018. Neurol Sci. 39: 717-724. PMID: 29441481
8. Interferon-γ Receptor 1 Deficiency Corrected by Umbilical Cord Blood Transplantation.  |  Michniacki, TF., et al. 2019. J Clin Immunol. 39: 257-260. PMID: 30953286
9. Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling.  |  Singh, S., et al. 2020. Nat Cell Biol. 22: 591-602. PMID: 32284542
10. Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study.  |  Kaymaz, S., et al. 2023. Arch Rheumatol. 38: 1-8. PMID: 37235124

The preferred IFN-γRα antibody is IFN-γRα Antibody (GIR-94): sc-12755.