IFN-γ/Interferon gamma Antibody (J-7): sc-74106

IFN-γ Antibody (J-7) is a mouse monoclonal IgG1 antibody that detects interferon gamma (IFN-γ) in mouse and rat samples through applications such as western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-IFN-γ antibody (J-7) plays a crucial role in the immune response, as IFN-γ is primarily produced by activated CD4+/CD8+ lymphocytes and natural killer cells, serving as a potent antiviral and antiparasitic agent. IFN-γ (J-7) antibody helps study a protein vital for modulating T cell growth and differentiation while inhibiting B cell proliferation, thereby orchestrating a balanced immune response. The active form of IFN-γ is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices, which is essential for biological activity. The precursor of IFN-γ consists of 166 amino acids, including a 23 amino acid secretory sequence, and functionality is further influenced by post-translational modifications such as glycosylation, which can lead to the formation of multiple isoforms under non-denaturing conditions, including dimers and tetramers. IFN-γ′s ability to interact with various signaling pathways highlights its importance in immune regulation and potential as a therapeutic target in diseases characterized by immune dysregulation.

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.