IFN-γ/Interferon gamma Antibody (FF6): sc-74104

IFN-γ Antibody (FF6) is a rat monoclonal IgG2a antibody that detects interferon gamma (IFN-γ) in mouse samples through applications such as western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IFN-γ plays a crucial role in the immune response, primarily functioning as an antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. Production of IFN-γ is stimulated by various factors, including antigens, mitogens, and alloantigens, and is essential for modulating T cell growth and differentiation while inhibiting B cell proliferation. The active form of IFN-γ is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and functionality is further enhanced by the presence of multiple forms resulting from variable glycosylation and the formation of dimers and tetramers under non-denaturing conditions. The ability of IFN-γ to interact with various signaling pathways underscores its importance in orchestrating immune responses, making anti-IFN-γ antibody (FF6) an invaluable tool for researchers studying immune function and related diseases.

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.