IFN-γ/Interferon gamma Antibody (F-1): sc-57207
- IFN-γ/Interferon gamma Antibody (F-1) is a rat monoclonal IgG2a, cited in 5 publications, provided at 100 µg/ml
- raised against recombinant full length IFN-γ protein of mouse origin
- recommended for detection of recombinant and native IFN-γ of mouse origin by IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (F-1). This work is in progress.
IFN-γ Antibody (F-1) is a rat monoclonal IgG2a antibody that detects Interferon (IFN)-γ in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IFN-γ plays a crucial role in the immune response, acting as an antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. IFN-γ modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby shaping the adaptive immune response. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The translated precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ′s functionality is further enhanced by the presence of multiple forms resulting from variable glycosylation and the formation of dimers and tetramers under non-denaturing conditions. The versatility of IFN-γ in immune modulation underscores its significance in therapeutic applications and research, making anti-IFN-γ antibody (F-1) an essential tool for studying immune responses in mouse models.
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IFN-γ/Interferon gamma Antibody (F-1) References:
- Regulation of tumor growth by IFN-gamma in cancer immunotherapy. | Beatty, GL. and Paterson, Y. 2001. Immunol Res. 24: 201-10. PMID: 11594457
- The role of IFN-gamma in surgical patients. | Schinkel, C. 2003. J Interferon Cytokine Res. 23: 341-9. PMID: 14511460
- Autophagy facilitates an IFN-γ response and signal transduction. | Chang, YP., et al. 2011. Microbes Infect. 13: 888-94. PMID: 21664983
- IFN-γ inhibits basal and α-MSH-induced melanogenesis. | Son, J., et al. 2014. Pigment Cell Melanoma Res. 27: 201-8. PMID: 24267286
- IFN-γ binds TPO to inhibit hematopoiesis. | Krause, DS. 2019. Blood. 133: 2004-2005. PMID: 31072961
- ADP-Ribosylation Regulates the Signaling Function of IFN-γ. | Menzel, S., et al. 2021. Front Immunol. 12: 642545. PMID: 33763084
- IFN-γ Signaling Sensitizes Melanoma Cells to BH3 Mimetics. | Ming, Z., et al. 2023. J Invest Dermatol. 143: 1246-1256.e8. PMID: 36736995
- IFN-γ Limits Immunopathogenesis but Delays Fungal Clearance during Pneumocystis Pneumonia. | Wang, J., et al. 2023. J Immunol. 211: 1397-1405. PMID: 37721419
- Tregs tame skin bacteria and IFN-γ-associated pathology. | Lionakis, MS. 2023. J Exp Med. 220: PMID: 37815549
- ISG15 is involved in chondrogenic differentiation through activation of IFN-γ signaling. | Hwang, HS., et al. 2024. Biochem Biophys Res Commun. 735: 150629. PMID: 39260332
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (F-1) | sc-57207 | 100 µg/ml | $322.00 |