IFN-γ/Interferon gamma Antibody (DB-14): sc-59992
- IFN-γ/Interferon gamma Antibody (DB-14) is a mouse monoclonal IgG2a, cited in 9 publications, provided at 100 µg/ml
- raised against IFN-γ of rat origin
- recommended for detection of IFN-γ of mouse and rat origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (DB-14). This work is in progress.
IFN-γ Antibody (DB-14) is a mouse monoclonal IgG2a antibody that detects interferon (IFN)-γ in mouse and rat samples through applications such as western blotting (WB) and immunoprecipitation (IP). IFN-γ plays a crucial role in the immune response, acting as a potent antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. IFN-γ modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby shaping the adaptive immune response. The active form of IFN-γ is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ functionality is further influenced by post-translational modifications such as glycosylation, leading to multiple forms under non-denaturing conditions, including dimers and tetramers. The versatility of IFN-γ in immune regulation underscores its significance in therapeutic applications and research, making anti-IFN-γ antibody (DB-14) an essential tool for studying immune responses in various biological contexts.
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IFN-γ/Interferon gamma Antibody (DB-14) References:
- IFN-gamma suspends the killing license of anti-tumor CTLs. | Lukacher, AE. 2002. J Clin Invest. 110: 1407-9. PMID: 12438437
- IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1. | Hu, X., et al. 2005. J Immunol. 175: 3637-47. PMID: 16148108
- Signaling through a mutant IFN-gamma receptor. | Costa-Pereira, AP., et al. 2005. J Immunol. 175: 5958-65. PMID: 16237089
- Regulatory T cell enrichment by IFN-γ conditioning. | Feng, G., et al. 2011. Methods Mol Biol. 677: 281-301. PMID: 20941618
- IFN-γ signals a changing of the guards. | Yap, GS. and Rivera, A. 2012. Immunity. 36: 904-6. PMID: 22749350
- Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling. | Lee, N., et al. 2014. Clin Immunol. 152: 101-10. PMID: 24657713
- IFN-γ Prevents Adenosine Receptor (A2bR) Upregulation To Sustain the Macrophage Activation Response. | Cohen, HB., et al. 2015. J Immunol. 195: 3828-37. PMID: 26355158
- IL-1 and IFN-gamma increase vascular permeability. | Martin, S., et al. 1988. Immunology. 64: 301-5. PMID: 3134297
- IFN-γ Mediates the Development of Systemic Lupus Erythematosus. | Liu, W., et al. 2020. Biomed Res Int. 2020: 7176515. PMID: 33123584
- IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. | Gupta, S., et al. 1997. J Clin Invest. 99: 2752-61. PMID: 9169506
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (DB-14) | sc-59992 | 100 µg/ml | $322.00 |