IFN-γ/Interferon gamma Antibody (DB-10): sc-59990

IFN-γ Antibody (DB-10) is a mouse monoclonal IgG1 antibody that detects interferon gamma (IFN-γ) in mouse and rat samples through applications such as western blotting (WB) and immunoprecipitation (IP). Anti-IFN-γ antibody (DB-10) plays a crucial role in studying immune response, as IFN-γ is primarily produced by activated CD4+/CD8+ lymphocytes and natural killer cells in response to antigens, mitogens, or alloantigens. IFN-γ monoclonal antibody (DB-10) helps researchers examine this cytokine′s essential role in modulating T cell growth and differentiation while inhibiting B cell proliferation, thereby influencing the overall immune landscape. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices, which is vital for biological activity. The precursor of IFN-γ consists of 166 amino acids, including a 23 amino acid secretory sequence, and functionality can be affected by various post-translational modifications, including glycosylation, which leads to the existence of multiple forms under non-denaturing conditions, such as dimers and tetramers. IFN-γ′s ability to interact with specific receptors and other proteins in the immune system underscores its importance in antiviral and antiparasitic defense mechanisms, making IFN-γ (DB-10) antibody an invaluable tool for researchers studying immune responses and cytokine signaling pathways.

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.