IEM 1925 dihydrobromide (CAS 258282-23-4)
Available in US only.
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IEM 1925 dihydrobromide (IEM 1925) emerges as a synthetic compound extensively investigated for its potential medical applications. It has demonstrated the ability to modulate various biochemical and physiological processes, including enzyme activity, gene expression, and hormone release. Moreover, IEM 1925 exhibits anti-inflammatory properties and confers protective effects on the cardiovascular system. While the precise mechanism of action for IEM 1925 remains under investigation, current understanding suggests that it binds to specific proteins within the cell membrane. This binding triggers a signaling pathway activation, resulting in the inhibition of cell proliferation and the induction of cell death. Additionally, IEM 1925 dihydrobromide has been identified as a voltage and use-dependent open-channel antagonist of AMPA receptors. It exhibits a higher efficacy in blocking receptors lacking the GluR2 subunit compared to those containing it.
IEM 1925 dihydrobromide (CAS 258282-23-4) References
- Gating and modulation of a hetero-octameric AMPA glutamate receptor. | Zhang, D., et al. 2021. Nature. 594: 454-458. PMID: 34079129
- Distinct forms of synaptic plasticity during ascending vs descending control of medial olivocochlear efferent neurons. | Romero, GE. and Trussell, LO. 2021. Elife. 10: PMID: 34250904
- Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor. | Herguedas, B., et al. 2022. Nat Commun. 13: 734. PMID: 35136046
- Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. | Zhang, D., et al. 2023. Nat Commun. 14: 1659. PMID: 36966141
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IEM 1925 dihydrobromide, 10 mg | sc-362748 | 10 mg | $413.00 | |||
| US: Only available in the US | ||||||
IEM 1925 dihydrobromide, 50 mg | sc-362748A | 50 mg | $872.00 | |||
| US: Only available in the US (Out of Stock: Availability September 12, 2025) | ||||||